日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.

两种 siRNA 组合在 SARS-CoV-2 临床前模型中表现出高抵抗屏障和预防性保护作用

Anglero-Rodriguez Yesseinia I, Lempp Florian A, Subramanian Megha, McIninch James, Schlegel Mark K, Bohan Dana, Wong Emily, Brown Christopher R, Foster Donald J, Castoreno Adam B, Nguyen Tuyen, Cuffe Dara, Montiel-Ruiz Martin, Kaiser Hannah, Sahakyan Anna, Spreafico Roberto, Morskaya Svetlana Shulga, Barry Joseph D, Berman Daniel, Zhang Ligang, Lefebvre Stephanie, Kasper Anne, Racie Timothy, Weddle Diann, Mobley Melissa, Wassarman Kelly, Bisbe Anna, Zlatev Ivan, Rogers Arlin, Nechev Lubomir, Dybowski Joseph, Chong Saeho, Nair Jayaprakash, Simon Amy, Sloan Kevin, Hwang Seungmin, Virgin Herbert W, Fitzgerald Kevin, Maier Martin A, Hinkle Gregory, Hebner Christy M, Akinc Akin, Jadhav Vasant

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

一项针对因子 XII (ALN-F12) 的在研 RNAi 疗法,用于治疗遗传性血管性水肿

Jingxuan Liu, June Qin, Anna Borodovsky, Timothy Racie, Adam Castoreno, Mark Schlegel, Martin A Maier, Tracy Zimmerman, Kevin Fitzgerald, James Butler, Akin Akinc

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

利用RNAi纳米颗粒调控基因表达作为肝脏功能基因组学的新型工具

Yin, Hao; Bogorad, Roman L; Barnes, Carmen; Walsh, Stephen; Zhuang, Iris; Nonaka, Hidenori; Ruda, Vera; Kuchimanchi, Satya; Nechev, Lubomir; Akinc, Akin; Xue, Wen; Zerial, Marino; Langer, Robert; Anderson, Daniel G; Koteliansky, Victor

Direct Visualization of the Hydration Layer on Alumina Nanoparticles with the Fluid Cell STEM in situ

利用流体池扫描透射电子显微镜原位直接观察氧化铝纳米颗粒上的水合层

Firlar, Emre; Çınar, Simge; Kashyap, Sanjay; Akinc, Mufit; Prozorov, Tanya

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

利用低分子量聚合物纳米颗粒进行体内内皮细胞siRNA递送

Dahlman, James E; Barnes, Carmen; Khan, Omar; Thiriot, Aude; Jhunjunwala, Siddharth; Shaw, Taylor E; Xing, Yiping; Sager, Hendrik B; Sahay, Gaurav; Speciner, Lauren; Bader, Andrew; Bogorad, Roman L; Yin, Hao; Racie, Tim; Dong, Yizhou; Jiang, Shan; Seedorf, Danielle; Dave, Apeksha; Sandu, Kamaljeet S; Webber, Matthew J; Novobrantseva, Tatiana; Ruda, Vera M; Lytton-Jean, Abigail K R; Levins, Christopher G; Kalish, Brian; Mudge, Dayna K; Perez, Mario; Abezgauz, Ludmila; Dutta, Partha; Smith, Lynelle; Charisse, Klaus; Kieran, Mark W; Fitzgerald, Kevin; Nahrendorf, Matthias; Danino, Dganit; Tuder, Rubin M; von Andrian, Ulrich H; Akinc, Akin; Schroeder, Avi; Panigrahy, Dipak; Kotelianski, Victor; Langer, Robert; Anderson, Daniel G

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

用于在啮齿动物和非人灵长类动物中高效选择性递送siRNA的脂肽纳米颗粒

Dong, Yizhou; Love, Kevin T; Dorkin, J Robert; Sirirungruang, Sasilada; Zhang, Yunlong; Chen, Delai; Bogorad, Roman L; Yin, Hao; Chen, Yi; Vegas, Arturo J; Alabi, Christopher A; Sahay, Gaurav; Olejnik, Karsten T; Wang, Weiheng; Schroeder, Avi; Lytton-Jean, Abigail K R; Siegwart, Daniel J; Akinc, Akin; Barnes, Carmen; Barros, Scott A; Carioto, Mary; Fitzgerald, Kevin; Hettinger, Julia; Kumar, Varun; Novobrantseva, Tatiana I; Qin, June; Querbes, William; Koteliansky, Victor; Langer, Robert; Anderson, Daniel G

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

脂质纳米颗粒的屏蔽作用及其对siRNA递送的影响:对理化性质、细胞因子诱导和疗效的影响

Kumar, Varun; Qin, June; Jiang, Yongfeng; Duncan, Richard G; Brigham, Benjamin; Fishman, Shannon; Nair, Jayaprakash K; Akinc, Akin; Barros, Scott A; Kasperkovitz, Pia V

The roles of individual mammalian argonautes in RNA interference in vivo

哺乳动物个体 argonautes 在体内 RNA 干扰中的作用

Vera M Ruda, Rohit Chandwani, Alfica Sehgal, Roman L Bogorad, Akin Akinc, Klaus Charisse, Alexander Tarakhovsky, Tatiana I Novobrantseva, Victor Koteliansky

Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics

可生物降解的脂质能够使脂质纳米颗粒快速清除,从而实现RNAi疗法的全身递送。

Maier, Martin A; Jayaraman, Muthusamy; Matsuda, Shigeo; Liu, Ju; Barros, Scott; Querbes, William; Tam, Ying K; Ansell, Steven M; Kumar, Varun; Qin, June; Zhang, Xuemei; Wang, Qianfan; Panesar, Sue; Hutabarat, Renta; Carioto, Mary; Hettinger, Julia; Kandasamy, Pachamuthu; Butler, David; Rajeev, Kallanthottathil G; Pang, Bo; Charisse, Klaus; Fitzgerald, Kevin; Mui, Barbara L; Du, Xinyao; Cullis, Pieter; Madden, Thomas D; Hope, Michael J; Manoharan, Muthiah; Akinc, Akin

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

聚乙二醇脂质解吸速率对siRNA脂质纳米颗粒药代动力学和药效学的影响

Mui, Barbara L; Tam, Ying K; Jayaraman, Muthusamy; Ansell, Steven M; Du, Xinyao; Tam, Yuen Yi C; Lin, Paulo Jc; Chen, Sam; Narayanannair, Jayaprakash K; Rajeev, Kallanthottathil G; Manoharan, Muthiah; Akinc, Akin; Maier, Martin A; Cullis, Pieter; Madden, Thomas D; Hope, Michael J