Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model
LY2457546 的发现:一种多靶点抗血管生成激酶抑制剂,在急性髓性白血病-Flt-3-内部串联重复突变人类肿瘤异种移植模型中具有新的活性范围和极好的药效
期刊:Investigational New Drugs
影响因子:3
doi:10.1007/s10637-011-9640-6
Timothy P Burkholder, Joshua R Clayton, Mark E Rempala, James R Henry, John M Knobeloch, David Mendel, Johnathan A McLean, Yan Hao, David A Barda, Eileen L Considine, Mark T Uhlik, Yuefeng Chen, Liandong Ma, Laura J Bloem, Jacqueline K Akunda, Denis J McCann, Manuel Sanchez-Felix, David K Clawson, M