日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer

发现和开发高效且选择性的双重NUAK/MARK抑制剂,作为Hippo通路调节剂用于癌症治疗

Smil, David; Liu, Yong; Xin, Tao; Kiyota, Taira; Aman, Ahmed; Grouleff, Julie; Hoffer, Laurent; Joshi, Dhananjay C; Inanlou, Mohammad R; Song, Siyuan; Mao, Daniel Y L; Ogunjimi, Abiodun A; Pau, Victor; Chini, Fiona D; Kurinov, Igor; Zhang, Ying; Nguyen, Anh Thu; Wrana, Jeffrey L; Sicheri, Frank; Attisano, Liliana; Uehling, David; Al-Awar, Rima; Isaac, Methvin B

Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.

针对极高危髓母细胞瘤中非同源末端连接与放射治疗之间的合成致死性进行靶向治疗

DeCarlo Alexandria, MacLeod Graham, Fernandes da Silva Carolina, Shen Li Qing, Povilaikaite Julija, Deane Madeline, Aragao Lucas, Sie Mariska, Termini Deborah, Magee Jonathan, Gudenas Brian, Sukumaran Sneha, Charron Frederic, Marcellus Richard, Al-Awar Rima, Aman Ahmed, Reynaud Denis, Trolat Amarine, Wybenga-Groot Leanne, Tabori Uri, Nör Carolina, Harding Shane M, Moran Michael F, Northcott Paul A, Dirks Peter, Angers Stephane, Ramaswamy Vijay

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

抑制去泛素化酶活性和炎症信号的分子胶

Chandler Francesca, Reddy Poli Adi Narayana, Bhutda Smita, Ross Rebecca L, Datta Arindam, Walden Miriam, Walker Kieran, Di Donato Stefano, Cassel Joel A, Prakesch Michael A, Aman Ahmed, Datti Alessandro, Campbell Lisa J, Foglizzo Martina, Bell Lillie, Stein Daniel N, Ault James R, Al-Awar Rima S, Calabrese Antonio N, Sicheri Frank, Del Galdo Francesco, Salvino Joseph M, Greenberg Roger A, Zeqiraj Elton

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

PRMT1 抑制剂 MS023 抑制 RNA 剪接,使小细胞肺癌对 DNA 损伤剂更加敏感

Aparnathi Mansi K, Ul Haq Sami, St-Germain Jonathan, Nixon Kevin C J, Walton Joseph, Song Lifang, Majeed Safa, Patel Parasvi S, Subramaniam Ratheesh, Philip Vivek, Marcellus Richard, Barsyte-Lovejoy Dalia, Al-Awar Rima, Hakem Razqallah, Arrowsmith Cheryl H, Ailles Laurie, Raught Brian, Lok Benjamin H

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

Discovery of Conformationally Constrained ALK2 Inhibitors

构象受限的ALK2抑制剂的发现

González-Álvarez, Héctor; Ensan, Deeba; Xin, Tao; Wong, Jong Fu; Zepeda-Velázquez, Carlos A; Cros, Julien; Sweeney, Melissa N; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J; Aman, Ahmed; Roberts, Owen; Isaac, Methvin B; Bullock, Alex N; Smil, David; Al-Awar, Rima

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding

CACHE(计算命中发现实验的关键评估):一项公私合作的基准测试计划,旨在促进命中发现计算方法的发展。

Ackloo, Suzanne; Al-Awar, Rima; Amaro, Rommie E; Arrowsmith, Cheryl H; Azevedo, Hatylas; Batey, Robert A; Bengio, Yoshua; Betz, Ulrich A K; Bologa, Cristian G; Chodera, John D; Cornell, Wendy D; Dunham, Ian; Ecker, Gerhard F; Edfeldt, Kristina; Edwards, Aled M; Gilson, Michael K; Gordijo, Claudia R; Hessler, Gerhard; Hillisch, Alexander; Hogner, Anders; Irwin, John J; Jansen, Johanna M; Kuhn, Daniel; Leach, Andrew R; Lee, Alpha A; Lessel, Uta; Morgan, Maxwell R; Moult, John; Muegge, Ingo; Oprea, Tudor I; Perry, Benjamin G; Riley, Patrick; Rousseaux, Sophie A L; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Schapira, Matthieu; Scholten, Cora; Todd, Matthew H; Vedadi, Masoud; Volkamer, Andrea; Willson, Timothy M

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

谱系定义的平滑肌肉瘤亚型在诊断前数年就已出现,并决定患者的生存期。

Anderson, Nathaniel D; Babichev, Yael; Fuligni, Fabio; Comitani, Federico; Layeghifard, Mehdi; Venier, Rosemarie E; Dentro, Stefan C; Maheshwari, Anant; Guram, Sheena; Wunker, Claire; Thompson, J Drew; Yuki, Kyoko E; Hou, Huayun; Zatzman, Matthew; Light, Nicholas; Bernardini, Marcus Q; Wunder, Jay S; Andrulis, Irene L; Ferguson, Peter; Razak, Albiruni R Abdul; Swallow, Carol J; Dowling, James J; Al-Awar, Rima S; Marcellus, Richard; Rouzbahman, Marjan; Gerstung, Moritz; Durocher, Daniel; Alexandrov, Ludmil B; Dickson, Brendan C; Gladdy, Rebecca A; Shlien, Adam

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

靶向ALK2:采用开放科学方法开发治疗弥漫性内生性脑桥胶质瘤的疗法

Ensan, Deeba; Smil, David; Zepeda-Velázquez, Carlos A; Panagopoulos, Dimitrios; Wong, Jong Fu; Williams, Eleanor P; Adamson, Roslin; Bullock, Alex N; Kiyota, Taira; Aman, Ahmed; Roberts, Owen G; Edwards, Aled M; O'Meara, Jeff A; Isaac, Methvin B; Al-Awar, Rima