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Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms

脑部自身免疫与新冠长期症状及其慢性疲劳综合征以及情感症状密切相关。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2024.11.011

Almulla, Abbas F; Maes, Michael; Zhou, Bo; Al-Hakeim, Hussein K; Vojdani, Aristo

In transfusion-dependent thalassemia, neuronal damage biomarkers are associated with affective and chronic fatigue symptoms

在输血依赖型地中海贫血中，神经元损伤生物标志物与情感障碍和慢性疲劳症状相关。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-16757-0

Ridhaa, Maha Abdul Saheb; Al-Hakeim, Hussein Kadhem; Kahlol, Mohammed K; Al-Naqeeb, Tabarek Hadi; Niu, Mengqi; Maes, Michael

Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson's disease

帕金森病患者的情感和慢性疲劳症状与血清神经元损伤标志物相关。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-07735-7

Al-Hakeim, Hussein Kadhem; Khudhair, Hayder Naji; Ranaei-Siadat, Sayed-Omid; Fatemi, Fataneh; Mirzajani, Fateme; Niu, Mengqi; Maes, Michael

Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID

长期新冠后遗症引起的情感症状和慢性疲劳综合征与促肾上腺皮质激素释放激素受体1（galanin-galanin receptor 1）信号传导增强、炎症和胰岛素抵抗有关。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0316373

Al Masoodi, Wasim Talib Mahdi; Radhi, Sami Waheed; Abdalsada, Habiba Khdair; Niu, Mengqi; Al-Hakeim, Hussein Kadhem; Maes, Michael

The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4

先兆子痫引起的抑郁症和慢性疲劳综合征的免疫检查点病理生理学：聚焦于sCD80和sCTLA-4

期刊:Acta Neuropsychiatrica

影响因子:2.5

doi:10.1017/neu.2025.10

Omar, Jangir Sami; Albarzinji, Niaz; Niu, Mengqi; Taher, Naz Hawree; Aram, Bayar; Sulaiman, Mohammed Salam; Moustafa, Shatha Rouf; Al-Hakeim, Hussein Kadhem; Maes, Michael

Role of Galanin system and insulin resistance parameters as predictive tools for diagnosis of Long-COVID patients

加兰素系统和胰岛素抵抗参数作为预测工具在诊断新冠长期症状患者中的作用

期刊:Biochemistry and Biophysics Reports

影响因子:2.2

doi:10.1016/j.bbrep.2025.102068

Al Masoodi, Wasim Talib; Radhi, Sami Waheed; Abdalsada, Habiba Khdair; Al-Hakeim, Hussein Kadhem

The interplay of serum cations, insulin resistance, and atherogenic indices in predicting depression in hypothyroid patients

血清阳离子、胰岛素抵抗和动脉粥样硬化指标在预测甲状腺功能减退患者抑郁症中的相互作用

期刊:Biotechnology Reports

影响因子:

doi:10.1016/j.btre.2025.e00932

Al-Baldawi, Sahira Qasim; Al-Hakeim, Hussein Kadhem; Hamam, Habib; Khémiri, Ikram

T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

白细胞介素-16激活辅助性T细胞-1是重度首发抑郁症急性期和自杀行为的关键现象。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2023.11.012

Almulla, Abbas F; Abbas Abo Algon, Ali; Tunvirachaisakul, Chavit; Al-Hakeim, Hussein K; Maes, Michael

The Potential Diagnostic Utility of SMAD4 and ACCS in the Context of Inflammation in Type 2 Diabetes Mellitus Patients

SMAD4和ACCS在2型糖尿病患者炎症背景下的潜在诊断价值

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines12092015

Abdalsada, Habiba Khdair; Abdulsaheb, Yusra Sebri; Zolghadri, Samaneh; Al-Hakeim, Hussein Kadhem; Stanek, Agata

SMAD4

炎症

炎症/感染

Immunology/Inflammation

The NLRP3 inflammasome as a key pathway in the affective and chronic fatigue symptoms of Long COVID

NLRP3炎症小体是新冠长期症状中情感和慢性疲劳症状的关键通路。

Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms

脑部自身免疫与新冠长期症状及其慢性疲劳综合征以及情感症状密切相关。

In transfusion-dependent thalassemia, neuronal damage biomarkers are associated with affective and chronic fatigue symptoms

在输血依赖型地中海贫血中，神经元损伤生物标志物与情感障碍和慢性疲劳症状相关。

Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson's disease

帕金森病患者的情感和慢性疲劳症状与血清神经元损伤标志物相关。

Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID

长期新冠后遗症引起的情感症状和慢性疲劳综合征与促肾上腺皮质激素释放激素受体1（galanin-galanin receptor 1）信号传导增强、炎症和胰岛素抵抗有关。

The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4

先兆子痫引起的抑郁症和慢性疲劳综合征的免疫检查点病理生理学：聚焦于sCD80和sCTLA-4

Role of Galanin system and insulin resistance parameters as predictive tools for diagnosis of Long-COVID patients

加兰素系统和胰岛素抵抗参数作为预测工具在诊断新冠长期症状患者中的作用

The interplay of serum cations, insulin resistance, and atherogenic indices in predicting depression in hypothyroid patients

血清阳离子、胰岛素抵抗和动脉粥样硬化指标在预测甲状腺功能减退患者抑郁症中的相互作用

T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

白细胞介素-16激活辅助性T细胞-1是重度首发抑郁症急性期和自杀行为的关键现象。

The Potential Diagnostic Utility of SMAD4 and ACCS in the Context of Inflammation in Type 2 Diabetes Mellitus Patients

SMAD4和ACCS在2型糖尿病患者炎症背景下的潜在诊断价值