日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

LEDGF/p75 对于造血可有可无,但对于 MLL 重排的白血病生成至关重要

Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman, Pieter Van Vlierberghe, Zeger Debyser, Jan De Rijck

CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors

CDK 4/6抑制剂可增强PIK3CA突变型乳腺癌对PI3K抑制剂的敏感性

Vora, Sadhna R; Juric, Dejan; Kim, Nayoon; Mino-Kenudson, Mari; Huynh, Tiffany; Costa, Carlotta; Lockerman, Elizabeth L; Pollack, Sarah F; Liu, Manway; Li, Xiaoyan; Lehar, Joseph; Wiesmann, Marion; Wartmann, Markus; Chen, Yan; Cao, Z Alexander; Pinzon-Ortiz, Maria; Kim, Sunkyu; Schlegel, Robert; Huang, Alan; Engelman, Jeffrey A

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

H171T 抗性机制揭示了 Nδ 质子化的 His171 对变构抑制剂 BI-D 与 HIV-1 整合酶结合的重要性

Alison Slaughter, Kellie A Jurado, Nanjie Deng, Lei Feng, Jacques J Kessl, Nikoloz Shkriabai, Ross C Larue, Hind J Fadel, Pratiq A Patel, Nivedita Jena, James R Fuchs, Eric Poeschla, Ronald M Levy, Alan Engelman, Mamuka Kvaratskhelia5

Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration

人类免疫缺陷病毒 1 型衣壳和细胞因子核孔蛋白 153 和 LEDGF/p75 对病毒 DNA 整合效率和特异性的不同影响

Yasuhiro Koh, Xiaolin Wu, Andrea L Ferris, Kenneth A Matreyek, Steven J Smith, KyeongEun Lee, Vineet N KewalRamani, Stephen H Hughes, Alan Engelman

Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity

持续性细胞内人类免疫缺陷病毒 1 型整合酶链转移抑制剂活性的鉴定和表征

Yasuhiro Koh, Hillel Haim, Alan Engelman

Differential sensitivities of retroviruses to integrase strand transfer inhibitors

逆转录病毒对整合酶链转移抑制剂的不同敏感性

Yasuhiro Koh, Kenneth A Matreyek, Alan Engelman

The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid

人类免疫缺陷病毒 1 型感染期间核孔蛋白 NUP153 的需要由病毒衣壳决定

Kenneth A Matreyek, Alan Engelman

Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity

转录辅激活因子 LEDGF 与 Cdc7-S 期激酶激活因子 (ASK) 相互作用并刺激其酶活性

Siobhan Hughes, Victoria Jenkins, Mohd Jamal Dar, Alan Engelman, Peter Cherepanov

The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase

感染期间对细胞转运蛋白 3(TNPO3 或 TRN-SR2)的需求与人类免疫缺陷病毒 1 型衣壳有关,而非整合酶

Lavanya Krishnan, Kenneth A Matreyek, Ilker Oztop, Kyeongeun Lee, Christopher H Tipper, Xiang Li, Mohd J Dar, Vineet N Kewalramani, Alan Engelman

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

晶状体上皮衍生的生长因子融合蛋白重定向 HIV-1 DNA 整合

Andrea L Ferris, Xiaolin Wu, Christina M Hughes, Claudia Stewart, Steven J Smith, Thomas A Milne, Gang G Wang, Ming-Chieh Shun, C David Allis, Alan Engelman, Stephen H Hughes