日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

CRISPR依赖性筛选在原代造血干细胞中发现KDM3B是IDH2和TET2突变细胞中基因型特异性的脆弱性

Michael R Waarts,Shoron Mowla,Meaghan Boileau,Anthony R Martinez Benitez,Junya Sango,Maya Bagish,Inés Fernández-Maestre,Yufan Shan,Shira E Eisman,Young C Park,Matthew Wereski,Isabelle Csete,Kavi O'Connor,Angelica C Romero-Vega,Linde A Miles,Wenbin Xiao,Xiaodi Wu,Richard P Koche,Scott A Armstrong,Alan H Shih,Eirini P Papapetrou,Jason M Butler,Sheng F Cai,Robert L Bowman,Ross L Levine

An MDM2 degrader for treatment of acute leukemias

用于治疗急性白血病的 MDM2 降解剂

Bridget K Marcellino #, Xiaobao Yang #, H Ümit Kaniskan #, Claudia Brady, He Chen, Karie Chen, Xing Qiu, Cara Clementelli, Lauren Herschbein, Zhijun Li, Sebastian Elghaity-Beckley, Joann Arandela, Brianna Kelly, Ronald Hoffman, Jing Liu, Yue Xiong, Jian Jin, Alan H Shih

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

合理靶向表观基因组的协同层可提高 AML 治疗效果

Cihangir Duy, Matt Teater, Francine E Garrett-Bakelman, Tak C Lee, Cem Meydan, Jacob L Glass, Meng Li, Johannes C Hellmuth, Helai P Mohammad, Kimberly N Smitheman, Alan H Shih, Omar Abdel-Wahab, Martin S Tallman, Monica L Guzman, David Muench, H Leighton Grimes, Gail J Roboz, Ryan G Kruger, Caretha

Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

突变型和野生型异柠檬酸脱氢酶 1 共享增强机制,涉及癌症中的不同酪氨酸激酶级联

Dong Chen #, Siyuan Xia #, Mei Wang #, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A Famulare, Alan H Shih, Cameron W Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O Pieper, Ashutosh Mishra, Junmin Peng, Martha Are

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

通过反式或顺式二聚体界面突变获得对IDH抑制的抗性

Andrew M Intlekofer, Alan H Shih, Bo Wang, Abbas Nazir, Ariën S Rustenburg, Steven K Albanese, Minal Patel, Christopher Famulare, Fabian M Correa, Naofumi Takemoto, Vidushi Durani, Hui Liu, Justin Taylor, Noushin Farnoud, Elli Papaemmanuil, Justin R Cross, Martin S Tallman, Maria E Arcila, Mikhail R

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

TET2缺失和NRAS突变协同表观遗传重塑驱动髓系转化和MEK抑制剂敏感性

Hiroyoshi Kunimoto ,Cem Meydan ,Abbas Nazir ,Justin Whitfield ,Kaitlyn Shank ,Franck Rapaport ,Rebecca Maher ,Elodie Pronier ,Sara C Meyer ,Francine E Garrett-Bakelman ,Martin Tallman ,Ari Melnick ,Ross L Levine ,Alan H Shih

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

TET2 缺陷导致生发中心增生,损害浆细胞分化,并促进 B 细胞淋巴瘤发生

Pilar M Dominguez # ,Hussein Ghamlouch # ,Wojciech Rosikiewicz # ,Parveen Kumar ,Wendy Béguelin ,Lorena Fontán ,Martín A Rivas ,Patrycja Pawlikowska ,Marine Armand ,Enguerran Mouly ,Miguel Torres-Martin ,Ashley S Doane ,María T Calvo Fernandez ,Matt Durant ,Veronique Della-Valle ,Matt Teater ,Luisa Cimmino ,Nathalie Droin ,Saber Tadros ,Samaneh Motanagh ,Alan H Shih ,Mark A Rubin ,Wayne Tam ,Iannis Aifantis ,Ross L Levine ,Olivier Elemento ,Giorgio Inghirami ,Michael R Green ,Maria E Figueroa ,Olivier A Bernard ,Said Aoufouchi ,Sheng Li ,Rita Shaknovich ,Ari M Melnick

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

TET2 缺陷导致生发中心增生,损害浆细胞分化,并促进 B 细胞淋巴瘤发生

Pilar M Dominguez #,Hussein Ghamlouch #,Wojciech Rosikiewicz #,Parveen Kumar,Wendy Béguelin,Lorena Fontán,Martín A Rivas,Patrycja Pawlikowska,Marine Armand,Enguerran Mouly,Miguel Torres-Martin,Ashley S Doane,María T Calvo Fernandez,Matt Durant,Veronique Della-Valle,Matt Teater,Luisa Cimmino,Nathalie Droin,Saber Tadros,Samaneh Motanagh,Alan H Shih,Mark A Rubin,Wayne Tam,Iannis Aifantis,Ross L Levine,Olivier Elemento,Giorgio Inghirami,Michael R Green,Maria E Figueroa,Olivier A Bernard,Said Aoufouchi,Sheng Li ,Rita Shaknovich,Ari M Melnick

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

JAK2/IDH突变驱动的骨髓增生性肿瘤对联合靶向抑制疗法敏感

Anna Sophia McKenney ,Allison N Lau ,Amritha Varshini Hanasoge Somasundara ,Barbara Spitzer ,Andrew M Intlekofer ,Jihae Ahn ,Kaitlyn Shank ,Franck T Rapaport ,Minal A Patel ,Efthymia Papalexi ,Alan H Shih ,April Chiu ,Elizaveta Freinkman ,Esra A Akbay ,Mya Steadman ,Raj Nagaraja ,Katharine Yen ,Julie Teruya-Feldstein ,Kwok-Kin Wong ,Raajit Rampal ,Matthew G Vander Heiden ,Craig B Thompson ,Ross L Levine

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

突变型IDH1下调ATM表达,并改变DNA修复和对DNA损伤的敏感性,且该过程独立于TET2。

Satoshi Inoue ,Wanda Y Li ,Alan Tseng ,Isabel Beerman ,Andrew J Elia ,Sean C Bendall ,François Lemonnier ,Ken J Kron ,David W Cescon ,Zhenyue Hao ,Evan F Lind ,Naoya Takayama ,Aline C Planello ,Shu Yi Shen ,Alan H Shih ,Dana M Larsen ,Qinxi Li ,Bryan E Snow ,Andrew Wakeham ,Jillian Haight ,Chiara Gorrini ,Christian Bassi ,Kelsie L Thu ,Kiichi Murakami ,Alisha R Elford ,Takeshi Ueda ,Kimberly Straley ,Katharine E Yen ,Gerry Melino ,Luisa Cimmino ,Iannis Aifantis ,Ross L Levine ,Daniel D De Carvalho ,Mathieu Lupien ,Derrick J Rossi ,Garry P Nolan ,Rob A Cairns ,Tak W Mak