日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration

HIV-1 利用混合电荷结构域依赖的 CPSF6 相分离进行更高级的衣壳结合、核内进入和病毒 DNA 整合。

Sooin Jang ,Gregory J Bedwell ,Satya P Singh ,Hyun Jae Yu ,Bjarki Arnarson ,Parmit K Singh ,Rajalingam Radhakrishnan ,AidanDarian W Douglas ,Zachary M Ingram ,Christian Freniere ,Onno Akkermans ,Stefan G Sarafianos ,Zandrea Ambrose ,Yong Xiong ,Praju V Anekal ,Paula Montero Llopis ,Vineet N KewalRamani ,Ashwanth C Francis ,Alan N Engelman

HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

HIV-1 整合体与过量整合酶 C 末端结构蛋白组装,有利于通过冷冻电镜进行结构研究,并揭示整合酶 C 末端尾部在 HIV-1 整合中的作用

Min Li, Zhen Li, Xuemin Chen, Yanxiang Cui, Alan N Engelman, Robert Craigie

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

环丝氨酸蛋白酶 A 和 CPSF6 与衣壳的时空结合调节 HIV-1 进入核并整合

Zachary Ingram, Christopher Kline, Alexandra K Hughson, Parmit K Singh, Hannah L Fischer, Gregory A Sowd, Simon C Watkins, Melissa Kane, Alan N Engelman, Zandrea Ambrose

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

HIV-1 整合酶寡聚结构揭示整合体组装和 RNA 结合的功能可塑性

Tao Jing, Zelin Shan, Tung Dinh, Avik Biswas, Sooin Jang, Juliet Greenwood, Min Li, Zeyuan Zhang, Gennavieve Gray, Hye Jeong Shin, Bo Zhou, Dario Passos, Sriram Aiyer, Zhen Li, Robert Craigie, Alan N Engelman, Mamuka Kvaratskhelia, Dmitry Lyumkis

Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels

利用核孔蛋白门控 DNA 折纸通道模拟 HIV-1 病毒进入细胞核

Qi Shen, Qingzhou Feng, Chunxiang Wu, Qiancheng Xiong, Taoran Tian, Shuai Yuan, Jiong Shi, Gregory J Bedwell, Ran Yang, Christopher Aiken, Alan N Engelman, C Patrick Lusk, Chenxiang Lin, Yong Xiong

Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration

全基因组 CRISPR/Cas9 转录激活筛选确定组蛋白乙酰转移酶抑制剂复合物是 HIV-1 整合的调节剂

Qiong Zhang, Shaobo Wang, Wanyu Li, Edwin Yau, Hui Hui, Parmit Kumar Singh, Vasudevan Achuthan, Maile Ann Young Karris, Alan N Engelman, Tariq M Rana

B-to-A transition in target DNA during retroviral integration

逆转录病毒整合过程中靶DNA的B到A转换

Ilona K Jóźwik ,Wen Li ,Da-Wei Zhang ,Doris Wong ,Julia Grawenhoff ,Allison Ballandras-Colas ,Sriram Aiyer ,Peter Cherepanov ,Alan N Engelman ,Dmitry Lyumkis

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

朊病毒样低复杂度区域使 HIV-1 感染期间病毒与宿主发生密切相互作用

Guochao Wei, Naseer Iqbal, Valentine V Courouble, Ashwanth C Francis, Parmit K Singh, Arpa Hudait, Arun S Annamalai, Stephanie Bester, Szu-Wei Huang, Nikoloz Shkriabai, Lorenzo Briganti, Reed Haney, Vineet N KewalRamani, Gregory A Voth, Alan N Engelman, Gregory B Melikyan, Patrick R Griffin, Francis

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

HIV-1 颗粒中天然和 eGFP 标记衣壳蛋白的定位和功能

Ashwanth C Francis, Anna Cereseto, Parmit K Singh, Jiong Shi, Eric Poeschla, Alan N Engelman, Christopher Aiken, Gregory B Melikyan

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors

变构整合酶抑制剂对 HIV-1 整合的影响以及 LEDGF/p75 和 HDGFL2 宿主因子的作用

Parmit Kumar Singh, Wen Li, Gregory J Bedwell, Hind J Fadel, Eric M Poeschla, Alan N Engelman