日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

SPAG7缺失导致宫内生长受限,从而导致成年期肥胖和代谢功能障碍

Stephen E Flaherty 3rd, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin, Andrew Robertson, Alan Opsahl, Dinesh Hirenallur Shanthappa, Youngwook Ahn, Evanthia Pashos, Rebecca A Simmons, Morris J Birnbaum, Zhidan Wu

GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia

GDF15 中和可恢复癌症恶病质小鼠模型的肌肉功能和身体机能

Ja Young Kim-Muller, LouJin Song, Brianna LaCarubba Paulhus, Evanthia Pashos, Xiangping Li, Anthony Rinaldi, Stephanie Joaquim, John C Stansfield, Jiangwei Zhang, Andrew Robertson, Jincheng Pang, Alan Opsahl, Magalie Boucher, Danna Breen, Katherine Hales, Abdul Sheikh, Zhidan Wu, Bei B Zhang

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

PF-06409577激活肝脏AMPK可纠正啮齿动物和灵长类动物临床前模型中的非酒精性脂肪性肝病并降低胆固醇

Ryan M Esquejo ,Christopher T Salatto ,Jake Delmore ,Bina Albuquerque ,Allan Reyes ,Yuji Shi ,Rob Moccia ,Emily Cokorinos ,Matthew Peloquin ,Mara Monetti ,Jason Barricklow ,Eliza Bollinger ,Brennan K Smith ,Emily A Day ,Chuong Nguyen ,Kieran F Geoghegan ,John M Kreeger ,Alan Opsahl ,Jessica Ward ,Amit S Kalgutkar ,David Tess ,Lynne Butler ,Norimitsu Shirai ,Timothy F Osborne ,Gregory R Steinberg ,Morris J Birnbaum ,Kimberly O Cameron ,Russell A Miller

FGF21 increases water intake, urine output and blood pressure in rats

FGF21 增加大鼠的饮水量、尿量和血压

Tod Turner, Xian Chen, Matthew Zahner, Alan Opsahl, George DeMarco, Magalie Boucher, Bryan Goodwin, Mylène Perreault

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

小鼠抗肌生长抑制素抗体可增加杜氏肌营养不良症 mdx 小鼠模型的肌肉质量并提高肌肉强度和收缩性,其人源化等效物 domagrozumab (PF-06252616) 可增加食蟹猴的肌肉体积

Michael St Andre, Mark Johnson, Prashant N Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M Burch, Peter Bialek, Carl Morris, Jane Owens