日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis

脂肪肝疾病各阶段人类肝脏和血液免疫细胞的单细胞图谱揭示了与肝功能障碍和纤维化相关的独特特征

Martin, Owen P; Wallace, Michael S; Oetheimer, Christopher; Patel, Hailey B; Butler, Michael D; Wong, Lai Ping; Huang, Pinzhu; Elbaz, Joshua; Costentin, Charlotte; Salloum, Shadi; Reinus, Zoe; Obinelo, Adaeze; Kim, Ulandt; Shroff, Stuti; Corey, Kathleen E; Popov, Yury V; Charles, Edgar D; Sadreyev, Ruslan I; Chung, Raymond T; Alatrakchi, Nadia

Whole-Genome Sequencing of Hepatitis B Virus Genotypes E and A in Zambia Reveals Limited Viral Diversity in HIV Coinfection

赞比亚乙型肝炎病毒E型和A型基因型的全基因组测序揭示了HIV合并感染中病毒多样性有限。

Vinikoor, Michael J; Walker, Andreas; Nsokolo, Bright; Musonda, Taonga; Muula, Guy; Michailidis, Eleftherios; Wandeler, Gilles; Alatrakchi, Nadia; Kelly, Paul; Damagnez, Maximillian; Le, Duyen Bao; Voges, Anja; Lübke, Nadine; Kanunga, Annie; Bosomprah, Samuel; Bhattacharya, Debika; Chibundi, Carolyn; Bwalya, Given; Musukuma-Chifulo, Kalo; Suslov, Aleksei; Feuerherd, Martin; Heim, Markus H; Schwartz, Robert E; Chung, Raymond T; Lauer, Georg; Sinkala, Edford; Timm, Jörg

Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis

慢性病毒性肝炎治愈前后肝脏髓系细胞的单细胞图谱

Cui, Ang; Li, Bo; Wallace, Michael S; Gonye, Anna L K; Oetheimer, Christopher; Patel, Hailey; Tonnerre, Pierre; Holmes, Jacinta A; Lieb, David; Yao, Brianna S; Ma, Aileen; Roberts, Kela; Damasio, Marcos; Chen, Jonathan H; Piou, Daphnee; Carlton-Smith, Charles; Brown, Joelle; Mylvaganam, Ravi; Hon Fung, Jeremy Man; Sade-Feldman, Moshe; Aneja, Jasneet; Gustafson, Jenna; Epstein, Eliana T; Salloum, Shadi; Brisac, Cynthia; Thabet, Ashraf; Kim, Arthur Y; Lauer, Georg M; Hacohen, Nir; Chung, Raymond T; Alatrakchi, Nadia

YAP mediates HIV-related liver fibrosis

YAP介导HIV相关的肝纤维化

Spalding, Volney A; Fellenstein, Brian A; Ahodantin, James; Jeyarajan, Andre J; Wang, Yongtao; Khan, Sanjoy K; Xu, Min; Lin, Wenyu; Alatrakchi, Nadia; Su, Lishan; Chung, Raymond T; Salloum, Shadi

New Window Into Hepatitis B in Africa: Liver Sampling Combined With Single-Cell Omics Enables Deep and Longitudinal Assessment of Intrahepatic Immunity in Zambia

非洲乙型肝炎研究新视角:肝脏取样结合单细胞组学技术,实现对赞比亚肝内免疫的深入纵向评估

Musonda, Taonga; Wallace, Michael S; Patel, Hailey; Martin, Owen P; Oetheimer, Christopher; Mwakamui, Simutanyi; Sinkala, Edford; Nsokolo, Bright; Kanunga, Annie; Lauer, Georg; Chung, Raymond T; Wandeler, Gilles; Bhattacharya, Debika; Kelly, Paul; Alatrakchi, Nadia; Vinikoor, Michael J

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

肝脏细针抽吸物的单细胞 RNA 测序可捕捉慢性乙型肝炎患者血液和肝脏中的免疫多样性

Alex S Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J G van de We

LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients

LOXL-2 和 TNC-C 是 HCV/HIV 合并感染、HIV 和 HCV 合并感染患者肝纤维化的标志物。

Altinbas, Akif; Holmes, Jacinta A; Salloum, Shadi; Lidofsky, Anna; Alatrakchi, Nadia; Somsouk, Ma; Hunt, Peter; Deeks, Steven; Chew, Kara W; Lauer, Georg; Kruger, Annie; Lin, Wenyu; Chung, Raymond T

Differentiation of exhausted CD8(+) T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

慢性抗原刺激终止后,耗竭的CD8(+) T细胞的分化未能达到功能性T细胞记忆的程度。

Tonnerre, Pierre; Wolski, David; Subudhi, Sonu; Aljabban, Jihad; Hoogeveen, Ruben C; Damasio, Marcos; Drescher, Hannah K; Bartsch, Lea M; Tully, Damien C; Sen, Debattama R; Bean, David J; Brown, Joelle; Torres-Cornejo, Almudena; Robidoux, Maxwell; Kvistad, Daniel; Alatrakchi, Nadia; Cui, Ang; Lieb, David; Cheney, James A; Gustafson, Jenna; Lewis-Ximenez, Lia L; Massenet-Regad, Lucile; Eisenhaure, Thomas; Aneja, Jasneet; Haining, W Nicholas; Chung, Raymond T; Hacohen, Nir; Allen, Todd M; Kim, Arthur Y; Lauer, Georg M

Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

脂肪酸激活转录共激活因子YAP1,通过p38丝裂原活化蛋白激酶促进肝纤维化。

Salloum, Shadi; Jeyarajan, Andre J; Kruger, Annie J; Holmes, Jacinta A; Shao, Tuo; Sojoodi, Mozhdeh; Kim, Myung-Ho; Zhuo, Zhu; Shroff, Stuti G; Kassa, Andrew; Corey, Kathleen E; Khan, Sanjoy K; Lin, Wenyu; Alatrakchi, Nadia; Schaefer, Esperance A K; Chung, Raymond T

Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis

在饮食诱导的非酒精性脂肪性肝炎小鼠模型中,长期使用塞尼西维罗克治疗可减轻脂肪性肝炎引起的肝纤维化。

Kruger, Annie J; Fuchs, Bryan C; Masia, Ricard; Holmes, Jacinta A; Salloum, Shadi; Sojoodi, Mozhdeh; Ferreira, Diego S; Rutledge, Stephanie M; Caravan, Peter; Alatrakchi, Nadia; Vig, Pam; Lefebvre, Eric; Chung, Raymond T