日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

脂肪酸合成是乳腺癌脑转移所必需的

Gino B Ferraro # ,Ahmed Ali # ,Alba Luengo # ,David P Kodack ,Amy Deik ,Keene L Abbott ,Divya Bezwada ,Landry Blanc ,Brendan Prideaux ,Xin Jin ,Jessica M Posada ,Jiang Chen ,Christopher R Chin ,Zohreh Amoozgar ,Raphael Ferreira ,Ivy X Chen ,Kamila Naxerova ,Christopher Ng ,Anna M Westermark ,Mark Duquette ,Sylvie Roberge ,Neal I Lindeman ,Costas A Lyssiotis ,Jens Nielsen ,David E Housman ,Dan G Duda ,Elena Brachtel ,Todd R Golub ,Lewis C Cantley ,John M Asara ,Shawn M Davidson ,Dai Fukumura ,Véronique A Dartois ,Clary B Clish ,Rakesh K Jain ,Matthew G Vander Heiden

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

与 ATP 相比,NAD+ 需求增加会促进有氧糖酵解

Alba Luengo, Zhaoqi Li, Dan Y Gui, Lucas B Sullivan, Maria Zagorulya, Brian T Do, Raphael Ferreira, Adi Naamati, Ahmed Ali, Caroline A Lewis, Craig J Thomas, Stefani Spranger, Nicholas J Matheson, Matthew G Vander Heiden

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

有限的环境丝氨酸和甘氨酸赋予脑转移对 PHGDH 抑制的敏感性

Bryan Ngo #, Eugenie Kim #, Victoria Osorio-Vasquez #, Sophia Doll, Sophia Bustraan, Roger J Liang, Alba Luengo, Shawn M Davidson, Ahmed Ali, Gino B Ferraro, Grant M Fischer, Roozbeh Eskandari, Diane S Kang, Jing Ni, Ariana Plasger, Vinagolu K Rajasekhar, Edward R Kastenhuber, Sarah Bacha, Roshan K

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

REV1 抑制剂 JH-RE-06 通过触发衰老标志增强肿瘤细胞对化疗的反应

Nimrat Chatterjee, Matthew A Whitman, Cynthia A Harris, Sophia M Min, Oliver Jonas, Evan C Lien, Alba Luengo, Matthew G Vander Heiden, Jiyong Hong, Pei Zhou, Michael T Hemann, Graham C Walker

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

反应性代谢物的产生是肺癌糖酵解代谢的一个可靶向的负担

Alba Luengo, Keene L Abbott, Shawn M Davidson, Aaron M Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G Zacharias, Thomas P Mathews, Clary B Clish, Ralph J DeBerardinis, Caroline A Lewis, Matthew G Vander Heiden

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

胰腺星状细胞释放脱氧胞苷促进吉西他滨耐药

Simona Dalin, Mark R Sullivan, Allison N Lau, Beatrice Grauman-Boss, Helen S Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A Lees, Matthew G Vander Heiden, Douglas A Lauffenburger, Michael T Hemann

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

当谷氨酰胺受限时,细胞浆天冬氨酸的可用性决定了细胞的存活率

H Furkan Alkan, Katharina E Walter, Alba Luengo, Corina T Madreiter-Sokolowski, Sarah Stryeck, Allison N Lau, Wael Al-Zoughbi, Caroline A Lewis, Craig J Thomas, Gerald Hoefler, Wolfgang F Graier, Tobias Madl, Matthew G Vander Heiden, Juliane G Bogner-Strauss

Aspartate is an endogenous metabolic limitation for tumour growth

天冬氨酸是肿瘤生长的内源性代谢限制因素

Lucas B Sullivan, Alba Luengo, Laura V Danai, Lauren N Bush, Frances F Diehl, Aaron M Hosios, Allison N Lau, Sarah Elmiligy, Scott Malstrom, Caroline A Lewis, Matthew G Vander Heiden

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

胰腺肿瘤中癌细胞自主细胞外蛋白质分解代谢的直接证据

Shawn M Davidson, Oliver Jonas, Mark A Keibler, Han Wei Hou, Alba Luengo, Jared R Mayers, Jeffrey Wyckoff, Amanda M Del Rosario, Matthew Whitman, Christopher R Chin, Kendall J Condon, Alex Lammers, Katherine A Kellersberger, Brian K Stall, Gregory Stephanopoulos, Dafna Bar-Sagi, Jongyoon Han, Joshua

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

环境影响 Ras 驱动的非小细胞肺癌的代谢依赖性

Shawn M Davidson, Thales Papagiannakopoulos, Benjamin A Olenchock, Julia E Heyman, Mark A Keibler, Alba Luengo, Matthew R Bauer, Abhishek K Jha, James P O'Brien, Kerry A Pierce, Dan Y Gui, Lucas B Sullivan, Thomas M Wasylenko, Lakshmipriya Subbaraj, Christopher R Chin, Gregory Stephanopolous, Bryan