日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase

一种基于共价片段的策略,靶向一种新型半胱氨酸,以抑制突变型EGFR激酶的活性。

Kuki, Naoki; Walmsley, David L; Kanai, Kazuo; Takechi, Sho; Yoshida, Masao; Murakami, Ryo; Takano, Kohei; Tominaga, Yuichi; Takahashi, Mizuki; Ito, Shuichiro; Nakao, Naoki; Angove, Hayley; Baker, Lisa M; Carter, Edward; Dokurno, Pawel; Le Strat, Loic; Macias, Alba T; Molyneaux, Carrie-Anne; Murray, James B; Surgenor, Allan E; Hamada, Tomoaki; Hubbard, Roderick E

A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors

台湾 H6N1 流感血凝素的单一突变可改变与人类受体的结合

Robert P de Vries, Netanel Tzarum, Wenjie Peng, Andrew J Thompson, Iresha N Ambepitiya Wickramasinghe, Alba T Torrents de la Pena, Marielle J van Breemen, Kim M Bouwman, Xueyong Zhu, Ryan McBride, Wenli Yu, Rogier W Sanders, Monique H Verheije, Ian A Wilson, James C Paulson

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase

解离速率筛选在鉴定新型丙酮酸脱氢酶激酶泛异构体抑制剂中的应用

Paul A Brough, Lisa Baker, Simon Bedford, Kirsten Brown, Seema Chavda, Victoria Chell, Jalanie D'Alessandro, Nicholas G M Davies, Ben Davis, Loic Le Strat, Alba T Macias, Daniel Maddox, Patrick C Mahon, Andrew J Massey, Natalia Matassova, Sean McKenna, Johannes W G Meissner, Jonathan D Moore, James

Three mutations switch H7N9 influenza to human-type receptor specificity

三个突变使H7N9流感病毒转变为人型受体特异性

de Vries, Robert P; Peng, Wenjie; Grant, Oliver C; Thompson, Andrew J; Zhu, Xueyong; Bouwman, Kim M; de la Pena, Alba T Torrents; van Breemen, Marielle J; Ambepitiya Wickramasinghe, Iresha N; de Haan, Cornelis A M; Yu, Wenli; McBride, Ryan; Sanders, Rogier W; Woods, Robert J; Verheije, Monique H; Wilson, Ian A; Paulson, James C

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

一种新型 Hsc70/Hsp70 小分子抑制剂可增强 Hsp90 抑制剂诱导的 HCT116 结肠癌细胞凋亡

Andrew J Massey, Douglas S Williamson, Helen Browne, James B Murray, Pawel Dokurno, Terry Shaw, Alba T Macias, Zoe Daniels, Stephanie Geoffroy, Melanie Dopson, Paul Lavan, Natalia Matassova, Geraint L Francis, Christopher J Graham, Rachel Parsons, Yikang Wang, Antony Padfield, Mike Comer, Martin J D

DNA bending induced by carbocyclic sugar analogs constrained to the north conformation

由碳环糖类似物诱导的DNA弯曲被限制在北构象

Macias, Alba T; Banavali, Nilesh K; MacKerell, Alexander D Jr

Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure

通过对活性ERK2结构的计算机模拟分析,鉴定出不依赖ATP的ERK抑制剂并对其进行表征。

Chen, Fengming; Hancock, Chad N; Macias, Alba T; Joh, Joseph; Still, Kimberly; Zhong, Shijun; MacKerell, Alexander D Jr; Shapiro, Paul