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Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

定量蛋白质组学定义了改良安卡拉痘苗感染期间抗病毒防御和细胞死亡的机制

Jonas D Albarnaz #, Joanne Kite #, Marisa Oliveira #, Hanqi Li, Ying Di, Maria H Christensen, Joao A Paulo, Robin Antrobus, Steven P Gygi, Florian I Schmidt, Edward L Huttlin, Geoffrey L Smith, Michael P Weekes

微生物学

Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses

痘苗病毒蛋白对 NF-κB 进行分子模拟，从而选择性抑制抗病毒反应

期刊:Nature Microbiology

影响因子:20.5

doi:10.1038/s41564-021-01004-9

Jonas D Albarnaz, Hongwei Ren, Alice A Torres, Evgeniya V Shmeleva, Carlos A Melo, Andrew J Bannister, Matthew P Brember, Betty Y-W Chung, Geoffrey L Smith

The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling

肌动蛋白成核剂 Spir-1 是一种病毒限制因子，可促进先天免疫信号传导

期刊:PLoS Pathogens

影响因子:5.5

doi:10.1371/journal.ppat.1010277

Alice A Torres, Stephanie L Macilwee, Amir Rashid, Sarah E Cox, Jonas D Albarnaz, Claudio A Bonjardim, Geoffrey L Smith

Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase

痘苗病毒B12假激酶对细胞VRK1、BAF和先天免疫信号传导的失调

期刊:Journal of Virology

影响因子:4

doi:10.1128/jvi.00398-22

Alexandria C Linville，Amber B Rico，Helena Teague，Lucy E Binsted，Geoffrey L Smith，Jonas D Albarnaz，Matthew S Wiebe

Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

痘苗病毒感染的定量时间蛋白质组学分析揭示了干扰素拮抗剂对组蛋白去乙酰化酶的调控

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2019.04.042

Lior Soday ，Yongxu Lu ，Jonas D Albarnaz ，Colin T R Davies ，Robin Antrobus ，Geoffrey L Smith ，Michael P Weekes

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

调节痘苗病毒免疫调节剂以改善免疫记忆

期刊:Viruses-Basel

影响因子:3.5

doi:10.3390/v10030101

Albarnaz, Jonas D; Torres, Alice A; Smith, Geoffrey L

Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation

痘苗病毒中的多种Bcl-2家族免疫调节因子调控MAPK/AP-1的激活。

期刊:Journal of General Virology

影响因子:4.3

doi:10.1099/jgv.0.000525

Torres, Alice A; Albarnaz, Jonas D; Bonjardim, Cláudio A; Smith, Geoffrey L

Acanthamoeba polyphaga mimivirus prevents amoebal encystment-mediating serine proteinase expression and circumvents cell encystment

棘阿米巴多噬拟病毒可阻止阿米巴包囊介导的丝氨酸蛋白酶表达，从而绕过细胞包囊形成。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/JVI.03177-14

Boratto, Paulo; Albarnaz, Jonas Dutra; Almeida, Gabriel Magno de Freitas; Botelho, Lucas; Fontes, Alide Caroline Lima; Costa, Adriana Oliveira; Santos, Daniel de Assis; Bonjardim, Cláudio Antônio; La Scola, Bernard; Kroon, Erna Geessien; Abrahão, Jônatas Santos

TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6

TRIM5α 可抑制痘病毒，并受到 CypA 和病毒蛋白 C6 的拮抗

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

定量蛋白质组学定义了改良安卡拉痘苗感染期间抗病毒防御和细胞死亡的机制

Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses

痘苗病毒蛋白对 NF-κB 进行分子模拟，从而选择性抑制抗病毒反应

The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling

肌动蛋白成核剂 Spir-1 是一种病毒限制因子，可促进先天免疫信号传导

Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase

痘苗病毒B12假激酶对细胞VRK1、BAF和先天免疫信号传导的失调

Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

痘苗病毒感染的定量时间蛋白质组学分析揭示了干扰素拮抗剂对组蛋白去乙酰化酶的调控

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

调节痘苗病毒免疫调节剂以改善免疫记忆

Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation

痘苗病毒中的多种Bcl-2家族免疫调节因子调控MAPK/AP-1的激活。

Acanthamoeba polyphaga mimivirus prevents amoebal encystment-mediating serine proteinase expression and circumvents cell encystment

棘阿米巴多噬拟病毒可阻止阿米巴包囊介导的丝氨酸蛋白酶表达，从而绕过细胞包囊形成。