日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

吞噬细胞作为斑块催化剂:人巨噬细胞产生具有交叉播散活性的、可播散斑块的Aβ42原纤维

Konstantoulea, Katerina; Ramakers, Meine; Borrie, Sarah C; T'Syen, Dries; Moechars, Daan; Sliwinska, Malgorzata A; Pradhan, Brajabandhu; Albertini, Giulia; Baligács, Nóra; Tsaka, Grigoria; Houben, Bert; Fiers, Mark; Gallardo, Rodrigo; Dewilde, Maarten; Thal, Dietmar Rudolf; Willem, Michael; Neher, Jonas J; De Strooper, Bart; Rousseau, Frederic; Schymkowitz, Joost

The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.

氯离子细胞内通道 1 (CLIC1) 对小胶质细胞形态动力学和神经炎症至关重要。

Rifat Ali, Bickel Tom, Kreis Patricia, Trimbuch Thorsten, Onken Julia, Ivanov Andranik, Albertini Giulia, Beule Dieter, Mazzanti Michele, Singh Harpreet, Eickholt Britta J, De Strooper Bart, Geiger Jörg R P, Madry Christian

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab 优先与阿尔茨海默病早期存在的较小聚集体结合

Fertan Emre, Lam Jeff Y L, Albertini Giulia, Dewilde Maarten, Wu Yunzhao, Akingbade Oluwatomi E S, Böken Dorothea, English Elizabeth A, De Strooper Bart, Klenerman David

Using anti‐Aβ antibodies to modulate the multi‐pronged human microglia response to Aβ pathology

利用抗Aβ抗体调节人类小胶质细胞对Aβ病理的多方面反应

Wang, Yuli; Li, Yingjie; Yi, Fei; Li, Junyu; Xie, Siwei; Peng, Qiyu; Xu, Jianfeng; Albertini, Giulia; Zielonka, Magdalena; Cuypers, Marie‐Lynn; van Lieshout, Veerle; Snellinx, An; Pasciuto, Emanuela; Wolfs, Leen; Craessaerts, Katleen; Horré, Katrien; Jaspers, Tom; Fiers, Mark; Dewilde, Maarten; De Strooper, Bart