Albone相关文献与解析，生知库 | 链接生命科学的每一步

Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity.

BB-1701 是一种靶向 HER2 的含艾立布林的抗体药物偶联物 (ADC)，具有强大的旁观者效应和 ICD 活性，其临床前研究

Wang Yang, Xia Bing, Cao Lixia, Yang Jianfeng, Feng Cui, Jiang Fangdun, Li Chen, Gu Lixia, Yang Yifan, Tian Jing, Cheng Xin, Furuuchi Keiji, Fulmer James, Verdi Arielle, Rybinski Katherine, Soto Allis, Albone Earl, Uenaka Toshimitsu, Gong Likun, Liu Tingting, Qin Qiuping, Wei Ziping, Zhou Yuhong

其它

药物研究

发表日期：2024

文献求助收藏

Survey of international experts on research priorities to improve care for healthy ageing

国际专家就改善健康老龄化护理的研究重点进行调查

期刊:Family Medicine and Community Health

影响因子:4.3

doi:10.1136/fmch-2023-002703

Cesari, Matteo; Sumi, Yuka; Jang, Hyobum; Amuthavalli Thiyagarajan, Jotheeswaran; Lee, Yejin; Albone, Rachel; Canevelli, Marco; Perracini, Monica R; Briggs, Andrew M; Banerjee, Anshu

发表日期：2024

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Antibody-drug conjugate MORAb-202 exhibits long-lasting antitumor efficacy in TNBC PDx models

抗体药物偶联物 MORAb-202 在 TNBC PDx 模型中表现出持久的抗肿瘤疗效

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.14898

Furuuchi, Keiji; Rybinski, Katherine; Fulmer, James; Moriyama, Tomoyuki; Drozdowski, Brian; Soto, Allis; Fernando, Shawn; Wilson, Kerrianne; Milinichik, Andrew; Dula, Mary Lou; Tanaka, Keigo; Cheng, Xin; Albone, Earl; Uenaka, Toshimitsu

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease

E2814是一种高亲和力抗体，靶向tau蛋白的微管结合重复结构域，用于阿尔茨海默病被动免疫治疗，本文对其进行了临床前表征。

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-020-0884-2

Malcolm Roberts ,Ioanna Sevastou ,Yoichi Imaizumi ,Kavita Mistry ,Sonia Talma ,Madhurima Dey ,Jane Gartlon ,Hiroshi Ochiai ,Zhi Zhou ,Shigeru Akasofu ,Naoki Tokuhara ,Makoto Ogo ,Muneo Aoyama ,Hirofumi Aoyagi ,Kate Strand ,Ezat Sajedi ,Kishan Lal Agarwala ,Jared Spidel ,Earl Albone ,Kanta Horie ,James M Staddon ,Rohan de Silva

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation

脂肪细胞 CD248 的特定缺失可通过减少白色脂肪组织缺氧、纤维化和炎症来改善代谢健康

期刊:EBioMedicine

影响因子:9.7

doi:10.1016/j.ebiom.2019.05.057

Paul Petrus, Tara L Fernandez, Michelle M Kwon, Jenny L Huang, Victor Lei, Nooshin Seyed Safikhan, Subashini Karunakaran, Daniel J O'Shannessy, Xiaowei Zheng, Sergiu-Bogdan Catrina, Earl Albone, Jukka Laine, Kirsi Virtanen, Susanne M Clee, Timothy J Kieffer, Christophe Noll, André C Carpentier, Jame

Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins

构建人源化抗体框架序列以实现细胞毒素的最佳位点特异性结合

期刊:MAbs

影响因子:5.6

doi:10.1080/19420862.2017.1330734

Jared L Spidel, Earl F Albone, Xin Cheng, Benjamin Vaessen, Sara Jacob, Andrew Z Milinichik, Arielle Verdi, J Bradford Kline, Luigi Grasso

Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus

利用穴兔轻链框架中的天然半胱氨酸，通过残基特异性结合技术 (RESPECT) 生成治疗性免疫结合物

期刊:Cancer Biology & Therapy

影响因子:4.4

doi:10.1080/15384047.2017.1312232

Earl F Albone, Jared L Spidel, Xin Cheng, Young Chul Park, Sara Jacob, Andrew Z Milinichik, Ben Vaessen, Janet Butler, J Bradford Kline, Luigi Grasso

免疫

发表日期：2017

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Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement

肿瘤抗原 CA125 通过直接抗体结合和抑制 Fc-γ 受体结合来抑制抗体依赖性细胞毒性 (ADCC)

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.19090

James Bradford Kline, Rina P Kennedy, Earl Albone, Qimin Chao, Shawn Fernando, Jennifer M McDonough, Katherine Rybinski, Wenquan Wang, Elizabeth B Somers, Charles Schweizer, Luigi Grasso, Nicholas C Nicolaides

Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe

艾格拉司他汀A的衍生化可得到生物活性类似物和三功能探针

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2016.02.051

Jouanneau, Morgan; McClary, Brandon; Reyes, Jeremy Chris P; Chen, Rong; Chen, Yuling; Plunkett, William; Cheng, Xin; Milinichik, Andrew Z; Albone, Earl F; Liu, Jun O; Romo, Daniel

发表日期：2016

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Supporting countries to ensure the continuum of integrated care for older people

支持各国确保为老年人提供持续的综合照护

Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity.

BB-1701 是一种靶向 HER2 的含艾立布林的抗体药物偶联物 (ADC)，具有强大的旁观者效应和 ICD 活性，其临床前研究

Survey of international experts on research priorities to improve care for healthy ageing

国际专家就改善健康老龄化护理的研究重点进行调查

Antibody-drug conjugate MORAb-202 exhibits long-lasting antitumor efficacy in TNBC PDx models

抗体药物偶联物 MORAb-202 在 TNBC PDx 模型中表现出持久的抗肿瘤疗效

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease

E2814是一种高亲和力抗体，靶向tau蛋白的微管结合重复结构域，用于阿尔茨海默病被动免疫治疗，本文对其进行了临床前表征。

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation

脂肪细胞 CD248 的特定缺失可通过减少白色脂肪组织缺氧、纤维化和炎症来改善代谢健康

Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins

构建人源化抗体框架序列以实现细胞毒素的最佳位点特异性结合

Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus

利用穴兔轻链框架中的天然半胱氨酸，通过残基特异性结合技术 (RESPECT) 生成治疗性免疫结合物

Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement

肿瘤抗原 CA125 通过直接抗体结合和抑制 Fc-γ 受体结合来抑制抗体依赖性细胞毒性 (ADCC)

Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe

艾格拉司他汀A的衍生化可得到生物活性类似物和三功能探针