Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
β-淀粉样蛋白通过加速血脑屏障内皮细胞（体外实验）和3XTg-AD小鼠体内LRP-1和IR-β的自噬-溶酶体降解，从而损害胰岛素信号传导。
期刊:Molecular and Cellular Neuroscience
影响因子:2.4
doi:10.1016/j.mcn.2019.103390
Gali, Chaitanya Chakravarthi; Fanaee-Danesh, Elham; Zandl-Lang, Martina; Albrecher, Nicole Maria; Tam-Amersdorfer, Carmen; Stracke, Anika; Sachdev, Vinay; Reichmann, Florian; Sun, Yidan; Avdili, Afrim; Reiter, Marielies; Kratky, Dagmar; Holzer, Peter; Lass, Achim; Kandimalla, Karunya K; Panzenboeck, Ute
血脑屏障
信号转导
神经科学
内皮细胞
细胞生物学
自噬
免疫/内分泌
