Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells
将缺乏 ζ 亚基的 CAR 整合到 CD3ζ 基因中,可赋予 T 细胞和 NK 细胞强大的细胞毒性。
期刊:Blood
影响因子:23.1
doi:10.1182/blood.2023020973
Kath, Jonas; Franke, Clemens; Drosdek, Vanessa; Du, Weijie; Glaser, Viktor; Fuster-Garcia, Carla; Stein, Maik; Zittel, Tatiana; Schulenberg, Sarah; Porter, Caroline E; Andersch, Lena; Künkele, Annette; Alcaniz, Joshua; Hoffmann, Jens; Abken, Hinrich; Abou-El-Enein, Mohamed; Pruß, Axel; Suzuki, Masataka; Cathomen, Toni; Stripecke, Renata; Volk, Hans-Dieter; Reinke, Petra; Schmueck-Henneresse, Michael; Wagner, Dimitrios L