Aldrich Courtney C相关文献与解析，生知库

Brinkmann, Marzena; Wong, Tsung-Yun Kent; Roopnarine, Osha; Yuen, Samantha L; Berg, Kaja; Cornea, Razvan L; Rebbeck, Robyn T; Thomas, David D; Aldrich, Courtney C

心力衰竭

心血管

发表日期：2026

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Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics

针对心脏兰尼碱受体靶向治疗药物的大规模高通量筛选

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.110951

Nikolaienko, Roman; Bovo, Elisa; Solberg, Jonathan C; Brinkmann, Marzena; Treinen, Levy M; Thompson, Andrew R; Berg, Kaja; Thomas, David D; Thomas, Jennifer J; Bers, Donald M; Aldrich, Courtney C; Zima, Aleksey V; Cornea, Razvan L; Rebbeck, Robyn T

信号转导

发表日期：2026

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Kupyaphores─Self-Assembling Diisocyanolipopeptide Zn(II) Ionophores in Mycobacterium tuberculosis Zn(II)/Cu(I/II) Homeostasis and Antibacterial Effects

结核分枝杆菌中自组装的二异氰基脂肽锌(II)离子载体——锌(II)/铜(I/II)稳态及抗菌作用

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.5c13262

Wong, Tsung-Yun; Sharma, Sachin; Mehdiratta, Kritee; Bhosale, Rashmi S; Nimmakayala, Kaavya; Wilharm, Randall K; Chakraborty, Arnab; Orimoloye, Moyosore; Liu, Qiang; Kamat, Siddhesh S; Pierre, Valérie C; Gokhale, Rajesh S; Aldrich, Courtney C

发表日期：2025

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Next-generation rifamycins for the treatment of mycobacterial infections

用于治疗分枝杆菌感染的新一代利福霉素

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2423842122

Dartois, Véronique; Lan, Tian; Ganapathy, Uday S; Wong, Chui Fann; Sarathy, Jickky P; Jimenez, Diana C; Alshiraihi, Ilham M; Lam, Ha; Rodriguez, Suyapa; Xie, Min; Soto-Ojeda, Maritza; Jackson, Mary; Wheat, William; Dillman, Nathan C; Kostenkova, Kateryna; Schmitt, Jake; Mann, Lea; Richter, Adrian; Imming, Peter; Sarathy, Jansy; Kaya, Firat; Paruchuri, Sindhuja; Tatek, Betelhem; Folvar, Camilla; Proietto, Julianna; Zimmerman, Matthew; Gonzalez-Juarrero, Mercedes; Aldrich, Courtney C; Dick, Thomas

炎症/感染

发表日期：2025

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Mycobactin and clofazimine activity are negatively correlated in mycobacteria

分枝杆菌素和氯法齐明的活性在分枝杆菌中呈负相关

期刊:Frontiers in Microbiology

影响因子:4.5

doi:10.3389/fmicb.2025.1539139

Voskuil, Martin I; Covey, Christopher R; Reichlen, Matthew J; Chatterjee, Anushila; Duerkop, Breck A; Dawadi, Surendra; Aldrich, Courtney C; Aaring, Alexander

发表日期：2025

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Central nervous system distributional kinetics of selected histone deacetylase inhibitors

选定的组蛋白去乙酰化酶抑制剂在中枢神经系统中的分布动力学

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1124/jpet.124.002170

Zhang, Wenqiu; Oh, Ju-Hee; Zhang, Wenjuan; Aldrich, Courtney C; Sirianni, Rachael W; Elmquist, William F

Mechanism of the dual action self-potentiating antitubercular drug morphazinamide

双重作用自增强抗结核药物吗啡酰胺的作用机制

期刊:PNAS Nexus

影响因子:3.8

doi:10.1093/pnasnexus/pgaf242

Ostrer, Lev; Crooks, Taylor A; Howe, Michael D; Vo, Sang; Jia, Ziyi; Hegde, Pooja; Schacht, Nathan; Aldrich, Courtney C; Baughn, Anthony D

发表日期：2025

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Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis

结构导向开发高效BioA抑制剂验证了生物素合成抑制作为结核病治疗策略的有效性

期刊:

影响因子:

doi:10.1101/2025.09.24.678246

Liu, Qiang; Wallach, Joshua B; Jayasinghe, Yahani P; Sullivan, Mark R; Proietto, Julianna; Rodriguez, Suyapa; Vo, Sang; Boshoff, Helena I M; Jia, Ziyi; Ostrer, Lev; Mehdiratta, Kritee; Shi, Rui; Dartois, Véronique; Baughn, Anthony D; Rubin, Eric J; Ronning, Donald R; Zimmerman, Matthew D; Schnappinger, Dirk; Aldrich, Courtney C

发表日期：2025

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Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability

帕比司他药代动力学：种间代谢稳定性差异

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1124/jpet.123.002051

Zhang, Wenqiu; Oh, Ju-Hee; Zhang, Wenjuan; Aldrich, Courtney C; Sirianni, Rachael W; Elmquist, William F

代谢

发表日期：2024

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PROTAC antibiotics: the time is now

PROTAC抗生素：时机已到

期刊:Expert Opinion on Drug Discovery

影响因子:4.9

doi:10.1080/17460441.2023.2178413

Sarathy, Jickky Palmae; Aldrich, Courtney C; Go, Mei-Lin; Dick, Thomas

发表日期：2023

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Development of activators for SERCA2a for heart failure treatments

开发用于治疗心力衰竭的SERCA2a激活剂

Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics

针对心脏兰尼碱受体靶向治疗药物的大规模高通量筛选

Kupyaphores─Self-Assembling Diisocyanolipopeptide Zn(II) Ionophores in Mycobacterium tuberculosis Zn(II)/Cu(I/II) Homeostasis and Antibacterial Effects

结核分枝杆菌中自组装的二异氰基脂肽锌(II)离子载体——锌(II)/铜(I/II)稳态及抗菌作用

Next-generation rifamycins for the treatment of mycobacterial infections

用于治疗分枝杆菌感染的新一代利福霉素

Mycobactin and clofazimine activity are negatively correlated in mycobacteria

分枝杆菌素和氯法齐明的活性在分枝杆菌中呈负相关

Central nervous system distributional kinetics of selected histone deacetylase inhibitors

选定的组蛋白去乙酰化酶抑制剂在中枢神经系统中的分布动力学

Mechanism of the dual action self-potentiating antitubercular drug morphazinamide

双重作用自增强抗结核药物吗啡酰胺的作用机制

Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis

结构导向开发高效BioA抑制剂验证了生物素合成抑制作为结核病治疗策略的有效性

Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability

帕比司他药代动力学：种间代谢稳定性差异

PROTAC antibiotics: the time is now

PROTAC抗生素：时机已到