Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease
通过工程化的 mitoARCUS 核酸酶有效消除与 MELAS 相关的 m.3243G 突变线粒体 DNA
期刊:Nature Metabolism
影响因子:18.9
doi:10.1038/s42255-023-00932-6
Wendy K Shoop, Janel Lape, Megan Trum, Alea Powell, Emma Sevigny, Adam Mischler, Sandra R Bacman, Flavia Fontanesi, Jeff Smith, Derek Jantz, Cassandra L Gorsuch, Carlos T Moraes
