日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lectin-type oxidized LDL receptor-1 as a potential therapeutic target for cerebral cavernous malformations treatment

凝集素型氧化低密度脂蛋白受体-1作为脑海绵状血管瘤治疗的潜在治疗靶点

Karthik Ashok, Tyra Martinez, Julie Sesen, Sana Nasim, Shih-Shan Lang, Gregory Heuer, Alexander Tucker, Miguel Alejandro Lopez-Ramirez, Edward R Smith, Aram Ghalali

Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration

与 N-炔丙基甘氨酸治疗相关的脑转录组学、代谢和线粒体兴奋特性:一种预防神经退行性疾病的策略

Fadzai Teramayi, Joanna Bons, Madeleine Scott, Gary K Scott, Ashley Loureiro, Alejandro Lopez-Ramirez, Birgit Schilling, Lisa M Ellerby, Christopher C Benz

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

患有脑海绵状血管瘤的小鼠的行为障碍与神经炎症有关

Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J Gonzalez, Stephan Anagnostaras, Miguel Alejandro Lopez-Ramirez

Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

亨廷顿病中型棘状神经元的蛋白质组学分析揭示了脂滴的改变

Kizito-Tshitoko Tshilenge ,Carlos Galicia Aguirre ,Joanna Bons ,Akos A Gerencser ,Nathan Basisty ,Sicheng Song ,Jacob Rose ,Alejandro Lopez-Ramirez ,Swati Naphade ,Ashley Loureiro ,Elena Battistoni ,Mateus Milani ,Cameron Wehrfritz ,Anja Holtz ,Claudio Hetz ,Sean D Mooney ,Birgit Schilling ,Lisa M Ellerby

β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations

β1整合素单克隆抗体治疗可改善脑海绵状血管畸形

Sara McCurdy ,Jenny Lin ,Robert Shenkar ,Thomas Moore ,Rhonda Lightle ,Eva Faurobert ,Miguel-Alejandro Lopez-Ramirez ,Issam Awad ,Mark H Ginsberg

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels

调节 FKBP5/FKBP51 和自噬降低 HTT(亨廷顿蛋白)水平

Barbara J Bailus, Stephen M Scheeler, Jesse Simons, Maria A Sanchez, Kizito-Tshitoko Tshilenge, Jordi Creus-Muncunill, Swati Naphade, Alejandro Lopez-Ramirez, Ningzhe Zhang, Kuruwitage Lakshika Madushani, Stanislav Moroz, Ashley Loureiro, Katherine H Schreiber, Felix Hausch, Brian K Kennedy, Michell

Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation

星形胶质细胞在脑海绵状血管瘤病变形成过程中促使神经血管功能障碍

Miguel Alejandro Lopez-Ramirez, Catherine Chinhchu Lai, Shady Ibrahim Soliman, Preston Hale, Angela Pham, Esau J Estrada, Sara McCurdy, Romuald Girard, Riya Verma, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Robert Shenkar, Orit Poulsen, Gabriel G Haddad, Richard Daneman, Brendan Gongol, Hao Sun,

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

N-炔丙基甘氨酸:一种独特的脯氨酸脱氢酶自杀抑制剂,具有抗癌活性和增强脑的线粒体兴奋特性

Gary K Scott #, Sophia Mahoney #, Madeleine Scott, Ashley Loureiro, Alejandro Lopez-Ramirez, John J Tanner, Lisa M Ellerby, Christopher C Benz

Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

抑制 HEG1-KRIT1 相互作用可增加内皮细胞中的 KLF4 和 KLF2 表达

Miguel Alejandro Lopez-Ramirez, Sara McCurdy, Wenqing Li, Mark K Haynes, Preston Hale, Karol Francisco, Killian Oukoloff, Matthew Bautista, Chelsea H J Choi, Hao Sun, Brendan Gongol, John Y Shyy, Carlo Ballatore, Larry A Sklar, Alexandre R Gingras

FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase

随着亨廷顿氏病神经细胞和纹状体神经元因 p16INK4a 增加而衰老,FOXO3 靶标被重新编程

Jessica Voisin, Francesca Farina, Swati Naphade, Morgane Fontaine, Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Alejandro Lopez-Ramirez, Julia Dancourt, Aurélie Ginisty, Satish Sasidharan Nair, Kuruwitage Lakshika Madushani, Ningzhe Zhang, François-Xavier Lejeune, Marc Verny, Judith Campisi, L