日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.

冷冻电镜揭示了β-arrestin 1通过Src SH3结构域介导Src激活的机制。

Pakharukova Natalia, Thomas Brittany N, Bansia Harsh, Li Linus, Bassford Dana K, Abzalimov Rinat R, Kim Jihee, Kahsai Alem W, Pani Biswaranjan, Xiao Kunhong, Ochakovski Roni, Liu Shibo, Zhang Xingdong, Ahn Seungkirl, des Georges Amedee, Lefkowitz Robert J

Correction: Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

更正:Gq活性和β-arrestin-1支架介导的ADGRG2/CFTR偶联是男性生育力所必需的。

Zhang, Dao-Lai; Sun, Yu-Jing; Ma, Ming-Liang; Wang, Yi-Jing; Lin, Hui; Li, Rui-Rui; Liang, Zong-Lai; Gao, Yuan; Yang, Zhao; He, Dong-Fang; Lin, Amy; Mo, Hui; Lu, Yu-Jing; Li, Mengjing; Kong, Wei; Chung, Ka Young; Yi, Fan; Li, Jian-Yuan; Qin, Ying-Ying; Li, Jingxin; Thomsen, Alex R B; Kahsai, Alem W; Chen, Zi-Jiang; Xu, Zhi-Gang; Liu, Mingyao; Li, Dali; Yu, Xiao; Sun, Jin-Peng

A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia

β1AR 的正向变构调节剂,对儿茶酚胺能多形性室性心动过速具有拮抗活性

Alyssa Grogan ,Robin M Perelli ,Seungkirl Ahn ,Haoran Jiang ,Arun Jyothidasan ,Damini Sood ,Chongzhao You ,David I Israel ,Alex Shaginian ,Qiuxia Chen ,Jian Liu ,Jialu Wang ,Jan Steyaert ,Alem W Kahsai ,Andrew P Landstrom ,Robert J Lefkowitz ,Howard A Rockman

Small-molecule modulation of β-arrestins

小分子对β-arrestin的调控

Kahsai, Alem W; Pakharukova, Natalia; Kwon, Henry Y; Shah, Kunal S; Liang-Lin, Jason G; Del Real, Caroline T; Shim, Paul J; Lee, Mason A; Ngo, Van A; Shreiber, Bowie N; Liu, Samuel; Schwalb, Allison M; Espinoza, Emmanuel F; Thomas, Brittany N; Kunzle, Cal A; Smith, Jeffrey S; Wang, Jialu; Kim, Jihee; Zhang, Xingdong; Rockman, Howard A; Thomsen, Alex R B; Rein, Lindsay A M; Shi, Lei; Ahn, Seungkirl; Masoudi, Ali; Lefkowitz, Robert J

Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes

V2R-βarrestin-Gβγ复合物在促进G蛋白转位至内体中的作用

Badr Sokrat #, Anthony H Nguyen #, Alex R B Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W Kahsai, Jihee Kim, Bing X Ho, Symon Ma, John Little 4th, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

低温电子显微镜揭示 Beta-arrestin 1 通过 Src SH3 结构域介导 Src 激活

Natalia Pakharukova, Brittany N Thomas, Harsh Bansia, Linus Li, Rinat R Abzalimov, Jihee Kim, Alem W Kahsai, Biswaranjan Pani, Dana K Bassford, Shibo Liu, Xingdong Zhang, Amedee des Georges, Robert J Lefkowitz

Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models

变构调节剂增强β2肾上腺素能受体激动剂在哮喘模型中促进的支气管保护作用

Ahn, Seungkirl; Maarsingh, Harm; Walker, Julia Kl; Liu, Samuel; Hegde, Akhil; Sumajit, Hyeje C; Kahsai, Alem W; Lefkowitz, Robert J

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

GPCR信号转导:β-arrestin对ERK MAPK的变构激活

Kahsai, Alem W; Shah, Kunal S; Shim, Paul J; Lee, Mason A; Shreiber, Bowie N; Schwalb, Allison M; Zhang, Xingdong; Kwon, Henry Y; Huang, Li-Yin; Soderblom, Erik J; Ahn, Seungkirl; Lefkowitz, Robert J

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

利用单分子精度解析GPCR介导的β-arrestin激活

Wesley B Asher ,Daniel S Terry ,G Glenn A Gregorio ,Alem W Kahsai ,Alessandro Borgia ,Bing Xie ,Arnab Modak ,Ying Zhu ,Wonjo Jang ,Alekhya Govindaraju ,Li-Yin Huang ,Asuka Inoue ,Nevin A Lambert ,Vsevolod V Gurevich ,Lei Shi ,Robert J Lefkowitz ,Scott C Blanchard ,Jonathan A Javitch

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

G蛋白偶联受体对Gαi和β-arrestin的非经典支架作用

Jeffrey S Smith # ,Thomas F Pack # ,Asuka Inoue ,Claudia Lee ,Kevin Zheng ,Issac Choi ,Dylan S Eiger ,Anmol Warman ,Xinyu Xiong ,Zhiyuan Ma ,Gayathri Viswanathan ,Ian M Levitan ,Lauren K Rochelle ,Dean P Staus ,Joshua C Snyder ,Alem W Kahsai ,Marc G Caron ,Sudarshan Rajagopal