日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intestinal macrophages modulate synucleinopathy along the gut-brain axis.

肠道巨噬细胞通过肠-脑轴调节突触核蛋白病。

De Schepper Sebastiaan, Konstantellos Viktoras, Conway James A, Sokolova Dimitra, Zaccagnini Ludovica, Cowley Matthew V, Sierksma Annerieke, Yudina Maria, Edmonds Marisa, Gavriouchkina Daria, Geary Bethany, Wallis Amber, Celikag Meral, Baykam Zeynep, Vara-Pérez Mónica, Crowley Gerard, Hager Fabian Tobias, Bijnen Mitchell, Posner David, Luk Kelvin, Cerovic Vuk, Clatworthy Menna, Videlock Elizabeth J, Jaunmuktane Zane, Movahedi Kiavash, Greter Melanie, Chain Benny, Alessi Dario R, Hong Soyon, Bartels Tim

C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia.

C9orf72 聚(甘氨酸-丙氨酸)敲入小鼠表现出轻微的旋转杆和蛋白质组变化,与肌萎缩侧索硬化症/额颞叶痴呆症一致。

Milioto Carmelo, Carcolé Mireia, Zanovello Matteo, Ahmed Mhoriam, Nirujogi Raja S, Biggs Daniel, Roberts Martha J, Schweers Kyra, Cammack Alexander J, Marchi Paolo M, Katona Eszter, Glaria Idoia, Santos Almudena, Devoy Anny, Fratta Pietro, Alessi Dario R, Davies Ben, Greensmith Linda, Fisher Elizabeth M C, Isaacs Adrian M

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage.

桥状脂质转运蛋白 VPS13C/PARK23 在溶酶体损伤后介导内质网-溶酶体接触

Wang Xinbo, Xu Peng, Bentley-DeSousa Amanda, Hancock-Cerutti William, Cai Shujun, Johnson Benjamin T, Tonelli Francesca, Shao Lin, Talaia Gabriel, Alessi Dario R, Ferguson Shawn M, De Camilli Pietro

NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway

NRBP1 和 TSC22D 蛋白通过调节 WNK 通路影响远曲小管的生理功能。

Magaña-Ávila, Germán; Carbajal-Contreras, Héctor; Amnekar, Ramchandra V; Dite, Toby; Téllez-Sutterlin, Michelle; García-Ávila, Kevin; Marquina-Castillo, Brenda; Lopez-Saavedra, Alejandro; Vazquez, Norma; Rojas-Ortega, Eréndira; Delpire, Eric; Ellison, David H; Alessi, Dario R; Gamba, Gerardo; Castañeda-Bueno, María

NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.

NRBP1 假激酶在渗透压应激下与 WNK 通路结合并激活该通路

Amnekar Ramchandra V, Dite Toby, Lis Pawel, Bell Sebastian, Brown Fiona, Johnson Clare, Wilkinson Stuart, Raggett Samantha, Dorward Mark, Wightman Mel, Macartney Thomas, Soares Renata F, Lamoliatte Frederic, Alessi Dario R

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson's disease.

深入的质谱分析揭示磷酸化 RAB12 是 G2019S LRRK2 驱动的帕金森病的血液生物标志物

Cortés Adriana, Phung Toan K, de Mena Lorena, Garrido Alicia, Infante Jon, Ruíz-Martínez Javier, Galmés-Ordinas Miquel À, Glendinning Sophie, Pérez Jesica, Roig Ana, Soto Marta, Cosgaya Marina, Ravasi Valeria, Fernández Manel, Rubiano-Castro Alejandro, Díaz Ramón, Hernández-Eguiazu Haizea, Sánchez-Quintana Coro, Vinagre-Aragón Ana, Mondragón Elisabet, Croitoru Ioana, Rivera-Sánchez María, Corrales-Pardo Andrea, Sierra María, Tolosa Eduardo, Malagelada Cristina, Nirujogi Raja S, Fernández-Irigoyen Joaquín, Santamaría Enrique, Alessi Dario R, Martí María J, Ezquerra Mario, Fernández-Santiago Rubén

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

内源性LRRK2和PINK1在大脑中发挥着趋同的神经保护性纤毛发生通路的作用

Bagnoli, Enrico; Lin, Yu-En; Burel, Sophie; Jaimon, Ebsy; Antico, Odetta; Themistokleous, Christos; Nikoloff, Jonas M; Squires, Samuel; Morella, Ilaria; Watzlawik, Jens O; Fiesel, Fabienne C; Springer, Wolfdieter; Tonelli, Francesca; Lis, Pawel; Brooks, Simon P; Dunnett, Stephen B; Brambilla, Riccardo; Alessi, Dario R; Pfeffer, Suzanne R; Muqit, Miratul M K

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.

PPM1M 是一种 LRRK2 拮抗剂,优先结合磷酸化 Rab12 的磷酸酶,可能与帕金森病有关。

Chiang Claire Y, Pratuseviciute Neringa, Lin Yu-En, Adhikari Ayan, Yeshaw Wondwossen M, Flitton Chloe, Sherpa Pemba L, Tonelli Francesca, Rektorova Irena, Lynch Timothy, Siuda Joanna, Rudzińska-Bar Monika, Pulyk Oleksandr, Bauer Peter, Beetz Christian, Dickson Dennis W, Ross Owen A, Wszolek Zbigniew K, Fang Zih-Hua, Klein Christine, Zimprich Alexander, Alessi Dario R, Sammler Esther M, Pfeffer Suzanne R

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.

富含亮氨酸重复激酶 2 会损害帕金森病易感多巴胺轴突的释放位点

Chen Chuyu, He Qianzi, Tombesi Giulia, Napier Eve, Jaconelli Matthew, Moreno-Ramos Oscar Andrés, Serio Hannah, Naaldijk Yahaira, Promes Vanessa, Schneeweis Amanda, Quinn Kaitlyn, Nasios Christopher, Greggio Elisa, Kozorovitskiy Yevgenia, Arango Daniel, Khan Amir R, Alessi Dario R, Dombeck Daniel A, Hilfiker Sabine, Awatramani Rajeshwar, Parisiadou Loukia

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

RAB32 Ser71Arg 与常染色体显性帕金森病:连锁、关联和功能分析

Gustavsson, Emil K; Follett, Jordan; Trinh, Joanne; Barodia, Sandeep K; Real, Raquel; Liu, Zhiyong; Grant-Peters, Melissa; Fox, Jesse D; Appel-Cresswell, Silke; Stoessl, A Jon; Rajput, Alex; Rajput, Ali H; Auer, Roland; Tilney, Russel; Sturm, Marc; Haack, Tobias B; Lesage, Suzanne; Tesson, Christelle; Brice, Alexis; Vilariño-Güell, Carles; Ryten, Mina; Goldberg, Matthew S; West, Andrew B; Hu, Michele T; Morris, Huw R; Sharma, Manu; Gan-Or, Ziv; Samanci, Bedia; Lis, Pawel; Periñan, Maria Teresa; Amouri, Rim; Ben Sassi, Samia; Hentati, Faycel; Tonelli, Francesca; Alessi, Dario R; Farrer, Matthew J