日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

在药物开发的早期阶段,整合计算机模拟、体外和原位工具,对新型心脏神经保护化合物进行预配制和表征

Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez

Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

控制被动扩散的血脑屏障微环境的物理化学选择性——与猪脑脂质提取物人工膜通透性模型相匹配

Oksana Tsinman, Konstantin Tsinman, Na Sun, Alex Avdeef

Biorelevant pK(a) (37 °C) predicted from the 2D structure of the molecule and its pK(a) at 25 °C

根据分子的二维结构预测生物相关的 pK(a) (37 °C) 及其在 25 °C 下的 pK(a)

Na Sun, Alex Avdeef