日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.

在果蝇强直性肌营养不良模型中,突触前和突触后 FasII 的上调协同作用,导致神经病理学和行为表型。

Koon Alex Chun, Yeung Ka Yee Winnie, Wu Yitao, Leong Lok I, Cheung John Tsun Po, Chen Zhefan Stephen, Peng Shaohong Isaac, Armstrong Noah S, Frank C Andrew, Magneron Paul, Gomes-Pereira Mário, Fung Joyce Man See, Bargiela Ariadna, Moreno Nerea, Poyatos-Garcia Javier, Vilchez Juan, Huguet-Lachon Aline, Brewer Cassandra Kussius, Zinter Max, Beck Erin S, Artero Rubén, Gourdon Genevieve, Budnik Vivian, Thomson Travis, McCabe Brian D, Chan Ho Yin Edwin

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.

突变亨廷顿蛋白通过解除对非经典聚腺苷酸聚合酶 PAPD5 的抑制来诱导神经元凋亡

Chen Zhefan Stephen, Peng Shaohong Isaac, Leong Lok I, Gall-Duncan Terence, Wong Nathan Siu Jun, Li Tsz Ho, Lin Xiao, Wei Yuming, Koon Alex Chun, Huang Junzhe, Sun Jacquelyne Ka-Li, Turner Clinton, Tippett Lynette, Curtis Maurice A, Faull Richard L M, Kwan Kin Ming, Chow Hei-Man, Ko Ho, Chan Ting-Fung, Talbot Kevin, Pearson Christopher E, Chan Ho Yin Edwin

Chinese patients with Lewy body dementia had shorter survival and developed complications earlier than those with Alzheimer's disease

患有路易体痴呆症的中国患者比患有阿尔茨海默病的患者生存期更短,并发症出现得更早。

Shea, Yat-Fung; Lee, Shui-Ching; Shum, Alex Chun Keung; Chiu, Patrick Ka-Chun; Chu, Leung-Wing; Chan, Hon Wai Felix

A Peptidylic Inhibitor for Neutralizing r(GGGGCC)exp-Associated Neurodegeneration in C9ALS-FTD

一种用于中和 C9ALS-FTD 中 r(GGGGCC)exp 相关神经变性的肽类抑制剂

Qian Zhang, Ying An, Zhefan Stephen Chen, Alex Chun Koon, Kwok-Fai Lau, Jacky Chi Ki Ngo, Ho Yin Edwin Chan

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

AQAMAN 是一种基于双脒的神经元毒性蛋白质内含物抑制剂,可改善聚谷氨酰胺疾病模型中的细胞毒性

Huiling Hong, Alex Chun Koon, Zhefan Stephen Chen, Yuming Wei, Ying An, Wen Li, Matthew Ho Yan Lau, Kwok-Fai Lau, Jacky Chi Ki Ngo, Chun-Ho Wong, Ho Yu Au-Yeung, Steven C Zimmerman, Ho Yin Edwin Chan

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

平面细胞极性基因 Fuz 在神经退行性疾病模型中引发细胞凋亡

Zhefan Stephen Chen, Li Li, Shaohong Peng, Francis M Chen, Qian Zhang, Ying An, Xiao Lin, Wen Li, Alex Chun Koon, Ting-Fung Chan, Kwok-Fai Lau, Jacky Chi Ki Ngo, Wing Tak Wong, Kin Ming Kwan, Ho Yin Edwin Chan

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

一种肽类抑制剂,用于中和多聚谷氨酰胺疾病中扩增的 CAG RNA 诱导的核仁应激。

Zhang, Qian; Chen, Zhefan Stephen; An, Ying; Liu, Haizhen; Hou, Yonghui; Li, Wen; Lau, Kwok-Fai; Koon, Alex Chun; Ngo, Jacky Chi Ki; Chan, Ho Yin Edwin

Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress

果蝇 Exo70 对神经突延伸和热应激下的存活至关重要

Alex Chun Koon, Zhefan Stephen Chen, Shaohong Peng, Joyce Man See Fung, Xiaoman Zhang, Kayly M Lembke, Hoi Kin Chow, C Andrew Frank, Liwen Jiang, Kwok-Fai Lau, Ho Yin Edwin Chan

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

神经元适配器 FE65 通过募集和激活 ELMO1 来刺激 Rac1 介导的神经突生长

Wen Li, Ka Ming Vincent Tam, Wai Wa Ray Chan, Alex Chun Koon, Jacky Chi Ki Ngo, Ho Yin Edwin Chan, Kwok-Fai Lau

A discourse analysis of the macro-structure, metadiscoursal and microdiscoursal features in the abstracts of research articles across multiple science disciplines

对多个科学学科研究论文摘要中的宏观结构、元话语和微观话语特征进行话语分析

Ngai, Sing Bik Cindy; Singh, Rita Gill; Koon, Alex Chun