日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread

在种子诱导的tau蛋白病模型中靶向内源性tau蛋白可抑制tau蛋白扩散。

Elliot Jang ,Kevt'her Hoxha ,Damian Mozier ,Abigail Insana ,Ethan Farber ,Lakshmi Changolkar ,Bin Zhang ,Tak-Ian Chio ,Alex Crowe ,Richard Chen ,Marc Mercken ,Edward B Lee ,Kelvin C Luk ,Kurt R Brunden ,Virginia M-Y Lee ,Hong Xu

Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model

在种子原代神经元模型中鉴定调节 tau 病理的小分子和相关靶点

Garrett S Gibbons, Hailey Gould, Virginia M-Y Lee, Alex Crowe, Kurt R Brunden

Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays

基于细胞的 tau 内含物形成模型中的化合物筛选:原代神经元和 HEK293 细胞测定的比较

Alex Crowe, Mark J Henderson, Johnathon Anderson, Steven A Titus, Alexey Zakharov, Anton Simeonov, Arjan Buist, Charlotte Delay, Diederik Moechars, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden

The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES

培养细胞中 Tau 聚集体的动态和周转:TAU 蛋白病的治疗见解

Jing L Guo, Arjan Buist, Alberto Soares, Kathleen Callaerts, Sara Calafate, Frederik Stevenaert, Joshua P Daniels, Bryan E Zoll, Alex Crowe, Kurt R Brunden, Diederik Moechars, Virginia M Y Lee

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

氨基噻吩并哒嗪和亚甲蓝通过半胱氨酸氧化影响 Tau 纤维化

Alex Crowe, Michael J James, Virginia M-Y Lee, Amos B Smith 3rd, John Q Trojanowski, Carlo Ballatore, Kurt R Brunden

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

油橄榄素通过与 tau 的氨基发生反应抑制 tau 纤维化

Wenkai Li, Jeffrey B Sperry, Alex Crowe, John Q Trojanowski, Amos B Smith 3rd, Virginia M-Y Lee