日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Network and pathway expansion of genetic disease associations identifies successful drug targets

遗传疾病关联的网络和通路扩展可确定成功的药物靶点

Aidan MacNamara, Nikolina Nakic, Ali Amin Al Olama, Cong Guo, Karsten B Sieber, Mark R Hurle, Alex Gutteridge

Single-cell RNAseq reveals seven classes of colonic sensory neuron

单细胞 RNA 测序揭示七类结肠感觉神经元

James R F Hockley, Toni S Taylor, Gerard Callejo, Anna L Wilbrey, Alex Gutteridge, Karsten Bach, Wendy J Winchester, David C Bulmer, Gordon McMurray, Ewan St John Smith

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability

GI-530159 是一种新型、选择性、机械敏感的双孔结构域钾 (K2P ) 通道开放剂,可降低大鼠背根神经节神经元兴奋性

Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Mathie

Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage

引导多能干细胞向视网膜色素上皮细胞系分化

Parul Choudhary, Heather Booth, Alex Gutteridge, Beata Surmacz, Irene Louca, Juliette Steer, Julie Kerby, Paul John Whiting

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

药物逆转 iPSC 衍生的感觉神经元和遗传性红斑性肢痛症患者的疼痛表型

Lishuang Cao, Aoibhinn McDonnell, Anja Nitzsche, Aristos Alexandrou, Pierre-Philippe Saintot, Alexandre J C Loucif, Adam R Brown, Gareth Young, Malgorzata Mis, Andrew Randall, Stephen G Waxman, Philip Stanley, Simon Kirby, Sanela Tarabar, Alex Gutteridge, Richard Butt, Ruth M McKernan, Paul Whiting,

Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium

靶向 cAMP 和转化生长因子-β 通路增加增殖,促进人类干细胞衍生的视网膜色素上皮细胞的再上皮化

Parul Choudhary, Alex Gutteridge, Emma Impey, R Ian Storer, Robert M Owen, Paul J Whiting, Magda Bictash, Caroline L Benn

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

亚型选择性小分子抑制剂揭示 Nav1.7 在伤害感受器电生成、轴突传导和突触前释放中的基本作用

Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation

骨髓间充质干细胞移植后视网膜反应性胶质增生的分子机制

Alessia Tassoni, Alex Gutteridge, Amanda C Barber, Andrew Osborne, Keith R Martin

A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells

视网膜色素上皮细胞中 FOXM1 依赖的间充质-上皮转化

Parul Choudhary, Benjamin Thomas Dodsworth, Ben Sidders, Alex Gutteridge, Christos Michaelides, Joshua Kane Duckworth, Paul John Whiting, Caroline Louise Benn

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research

在单细胞水平上表征人类干细胞衍生的感觉神经元揭示了它们的离子通道表达及其在疼痛研究中的效用

Gareth T Young, Alex Gutteridge, Heather DE Fox, Anna L Wilbrey, Lishuang Cao, Lily T Cho, Adam R Brown, Caroline L Benn, Laura R Kammonen, Julia H Friedman, Magda Bictash, Paul Whiting, James G Bilsland, Edward B Stevens