Alex MacKenzie相关文献与解析，生知库 | 链接生命科学的每一步

High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)

高通量激酶组-RNAi 筛选鉴定出蛋白激酶 R 激活剂 (PACT) 是 1 型强直性肌营养不良症 (DM1) 中 CUG 病灶完整性的新型遗传修饰因子

doi:10.1371/journal.pone.0256276

Nafisa Neault, Sean O'Reilly, Aiman Tariq Baig, Julio Plaza-Diaz, Mehrdad Azimi, Faraz Farooq, Stephen D Baird, Alex MacKenzie

Separating the Wheat from the Chaff: The Use of Upstream Regulator Analysis to Identify True Differential Expression of Single Genes within Transcriptomic Datasets

去芜存菁：利用上游调节因子分析来识别转录组数据集中单个基因的真正差异表达

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms22126295

Jeremiah Hadwen, Sarah Schock, Faraz Farooq, Alex MacKenzie, Julio Plaza-Diaz

信号转导

发表日期：2021

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Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review

中链酰基辅酶A脱氢酶（MCAD）缺乏症和苯丙酮尿症（PKU）儿科研究结果：综述

期刊:Orphanet Journal of Rare Diseases

影响因子:3.5

doi:10.1186/s13023-019-1276-1

Pugliese, Michael; Tingley, Kylie; Chow, Andrea; Pallone, Nicole; Smith, Maureen; Rahman, Alvi; Chakraborty, Pranesh; Geraghty, Michael T; Irwin, Julie; Tessier, Laure; Nicholls, Stuart G; Offringa, Martin; Butcher, Nancy J; Iverson, Ryan; Clifford, Tammy J; Stockler, Sylvia; Hutton, Brian; Paik, Karen; Tao, Jessica; Skidmore, Becky; Coyle, Doug; Duddy, Kathleen; Dyack, Sarah; Greenberg, Cheryl R; Ghai, Shailly Jain; Karp, Natalya; Korngut, Lawrence; Kronick, Jonathan; MacKenzie, Alex; MacKenzie, Jennifer; Maranda, Bruno; Mitchell, John J; Potter, Murray; Prasad, Chitra; Schulze, Andreas; Sparkes, Rebecca; Taljaard, Monica; Trakadis, Yannis; Walia, Jagdeep; Potter, Beth K

发表日期：2020

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Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

巨噬细胞分化和 M1/M2 极化过程中凋亡蛋白、NAIP、cIAP1 和 cIAP2 表达的抑制剂

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0193643

Virginia Morón-Calvente, Salvador Romero-Pinedo, Sofía Toribio-Castelló, Julio Plaza-Díaz, Ana C Abadía-Molina, Domingo I Rojas-Barros, Shawn T Beug, Eric C LaCasse, Alex MacKenzie, Robert Korneluk, Francisco Abadía-Molina

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

通过鳍片剪取法对 3dpf 斑马鱼幼体进行高通量 DNA 提取和基因分型

期刊:Jove-Journal of Visualized Experiments

影响因子:1.2

doi:10.3791/58024

Ceres Kosuta, Kate Daniel, Devon L Johnstone, Kevin Mongeon, Kevin Ban, Sophie LeBlanc, Stuart MacLeod, Karim Et-Tahiry, Marc Ekker, Alex MacKenzie, Izabella Pena

发表日期：2018

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Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen

挖掘转录组用于罕见疾病治疗：两种数据挖掘方法和基于细胞的靶向药物筛选的效率比较

期刊:npj Genomic Medicine

影响因子:4.7

doi:10.1038/s41525-017-0018-3

A J Mears, S C Schock, J Hadwen, S Putos, D Dyment, K M Boycott, Alex MacKenzie

Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division

神经元凋亡抑制蛋白（NAIP）在细胞分裂过程中定位于胞质分裂装置。

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/srep39981

Francisco Abadía-Molina ,Virginia Morón-Calvente ,Stephen D Baird ,Fahad Shamim ,Francisco Martín ,Alex MacKenzie

Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

Aldh7a1 缺乏导致斑马鱼发生吡哆醇依赖性癫痫

期刊:Genetics

影响因子:3.3

doi:10.1534/genetics.117.300137

Izabella A Pena, Yann Roussel, Kate Daniel, Kevin Mongeon, Devon Johnstone, Hellen Weinschutz Mendes, Marjolein Bosma, Vishal Saxena, Nathalie Lepage, Pranesh Chakraborty, David A Dyment, Clara D M van Karnebeek, Nanda Verhoeven-Duif, Tuan Vu Bui, Kym M Boycott, Marc Ekker, Alex MacKenzie

Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance

对欧洲白血病网MDS（EUMDS）登记处100例新诊断的低危MDS患者的细胞形态学回顾显示，观察者间一致性较高。

期刊:Annals of Hematology

影响因子:2.4

doi:10.1007/s00277-017-3009-7

de Swart, Louise; Smith, Alex; MacKenzie, Marius; Symeonidis, Argiris; Neukirchen, Judith; Mikulenková, Dana; Vallespí, Teresa; Zini, Gina; Paszkowska-Kowalewska, Malgorzata; Kruger, Anton; Saft, Leonie; Fenaux, Pierre; Bowen, David; Hellström-Lindberg, Eva; Čermák, Jaroslav; Stauder, Reinhard; Tatic, Aurelia; Holm, Mette Skov; Malcovati, Luca; Mądry, Krzysztof; Droste, Jackie; Blijlevens, Nicole; de Witte, Theo; Germing, Ulrich

Efficient proton transport modelling for proton beam therapy and biological quantification

用于质子束治疗和生物定量分析的高效质子传输模型

High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)

高通量激酶组-RNAi 筛选鉴定出蛋白激酶 R 激活剂 (PACT) 是 1 型强直性肌营养不良症 (DM1) 中 CUG 病灶完整性的新型遗传修饰因子

Separating the Wheat from the Chaff: The Use of Upstream Regulator Analysis to Identify True Differential Expression of Single Genes within Transcriptomic Datasets

去芜存菁：利用上游调节因子分析来识别转录组数据集中单个基因的真正差异表达

Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review

中链酰基辅酶A脱氢酶（MCAD）缺乏症和苯丙酮尿症（PKU）儿科研究结果：综述

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

巨噬细胞分化和 M1/M2 极化过程中凋亡蛋白、NAIP、cIAP1 和 cIAP2 表达的抑制剂

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

通过鳍片剪取法对 3dpf 斑马鱼幼体进行高通量 DNA 提取和基因分型

Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen

挖掘转录组用于罕见疾病治疗：两种数据挖掘方法和基于细胞的靶向药物筛选的效率比较

Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division

神经元凋亡抑制蛋白（NAIP）在细胞分裂过程中定位于胞质分裂装置。

Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

Aldh7a1 缺乏导致斑马鱼发生吡哆醇依赖性癫痫

Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance

对欧洲白血病网MDS（EUMDS）登记处100例新诊断的低危MDS患者的细胞形态学回顾显示，观察者间一致性较高。