日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Modular design of bi- and multi-specific knob domain fusions

双特异性和多特异性旋钮域融合的模块化设计

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2024.1384467
Mikhail Kuravsky ,Glyn F Gibbons ,Callum Joyce ,Anthony Scott-Tucker ,Alex Macpherson ,Alastair D G Lawson
发表日期：2024
文献求助 收藏

Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

在 VH 框架 III 双特异性抗体形式内和作为嵌合肽设计的血清白蛋白结合旋钮结构域

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2023.1170357
Ralph Adams, Callum Joyce, Mikhail Kuravskiy, Katriona Harrison, Zainab Ahdash, Matthew Balmforth, Kelda Chia, Cinzia Marceddu, Matthew Coates, James Snowden, Emmanuel Goursaud, Karelle Ménochet, Jean van den Elsen, Richard J Payne, Alastair D G Lawson, Anthony Scott-Tucker, Alex Macpherson
信号转导
发表日期：2023
文献求助 收藏

The proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains

牛旋钮结构域的 N 端和 C 端接近，使得能够将靶标特异性设计到多肽链中

期刊:MAbs
影响因子:5.6
doi:10.1080/19420862.2022.2076295
Alice Hawkins, Callum Joyce, Kevin Brady, Adam Hold, Alan Smith, Michael Knight, Conor Howard, Jean van den Elsen, Alastair D G Lawson, Alex Macpherson
信号转导
Bovine
发表日期：2022
文献求助 收藏

The allosteric modulation of complement C5 by knob domain peptides

旋钮结构域肽对补体 C5 的变构调节

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.63586
Alex Macpherson, Maisem Laabei, Zainab Ahdash, Melissa A Graewert, James R Birtley, Monika-Sarah Ed Schulze, Susan Crennell, Sarah A Robinson, Ben Holmes, Vladas Oleinikovas, Per H Nilsson, James Snowden, Victoria Ellis, Tom Eirik Mollnes, Charlotte M Deane, Dmitri Svergun, Alastair Dg Lawson, Jean
信号转导
发表日期：2021
文献求助 收藏

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

深入了解二聚 C3d 片段的结构-功能关系

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2021.714055
Ayla A Wahid, Rhys W Dunphy, Alex Macpherson, Beth G Gibson, Liudmila Kulik, Kevin Whale, Catherine Back, Thomas M Hallam, Bayan Alkhawaja, Rebecca L Martin, Ingrid Meschede, Maisem Laabei, Alastair D G Lawson, V Michael Holers, Andrew G Watts, Susan J Crennell, Claire L Harris, Kevin J Marchbank, J
发表日期：2021
文献求助 收藏

A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity

补体 C5 的构象变化是凝血酶介导的裂解所必需的，通过一种保留全部凝血酶活性的新型离体人全血模型揭示

期刊:Journal of Immunology
影响因子:3.6
doi:10.4049/jimmunol.2001471
Per H Nilsson, Christina Johnson, Quang Huy Quach, Alex Macpherson, Oliver Durrant, Soeren E Pischke, Hilde Fure, Anne Landsem, Grethe Bergseth, Camilla Schjalm, Linda M Haugaard-Kedström, Markus Huber-Lang, Jean van den Elsen, Ole-Lars Brekke, Tom Eirik Mollnes3
Human
免疫/内分泌
发表日期：2021
文献求助 收藏

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies

从牛抗体中分离抗原特异性、富含二硫键的旋钮结构域肽

期刊:PLoS Biology
影响因子:7.8
doi:10.1371/journal.pbio.3000821
Alex Macpherson, Anthony Scott-Tucker, Anastasios Spiliotopoulos, Catherine Simpson, Justin Staniforth, Adam Hold, James Snowden, Leah Manning, Jean van den Elsen, Alastair D G Lawson
发表日期：2020
文献求助 收藏

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

通过 X 射线晶体学和 100 kHz 魔角旋转 NMR 深入了解小分子与新生儿 Fc 受体的结合

期刊:PLoS Biology
影响因子:7.8
doi:10.1371/journal.pbio.2006192
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox 3rd,
信号转导
发表日期：2018
文献求助 收藏

The rational design of affinity-attenuated OmCI for the purification of complement C5

亲和力减弱的OmCI纯化补体C5的合理设计

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.RA118.004043
Alex Macpherson, Xiaofeng Liu, Neesha Dedi, Jeffery Kennedy, Bruce Carrington, Oliver Durrant, Sam Heywood, Jean van den Elsen, Alastair D G Lawson
免疫/内分泌
发表日期：2018
文献求助 收藏