日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay

通过一种新型体外试验阐明B细胞特异性药物免疫原性风险

Cary M Looney ,Axel Ducret ,Guido Steiner ,Karen Dernick ,Katharina Hartman ,Michel Siegel ,Timothy Hickling ,Alex Odermatt ,Céline Marban-Doran

Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development

血脑屏障类器官的先进组织技术作为药物开发中的高通量毒性读数

Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar-Regenscheit

In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1

通过计算机模拟和体外评估可能通过抑制 CYP17A1 而产生不良影响的药物

Jacek Kędzierski, Marie-Christin Jäger, Sadaf Naeem, Alex Odermatt, Martin Smieško

ER-mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein

内质网-线粒体接触和胆固醇代谢被疾病相关的 tau 蛋白破坏

Leonora Szabo, Nadia Cummins, Paolo Paganetti, Alex Odermatt, Andreas Papassotiropoulos, Celeste Karch, Jürgen Götz, Anne Eckert, Amandine Grimm

Calcineurin regulates aldosterone production via dephosphorylation of NFATC4

钙调神经磷酸酶通过 NFATC4 去磷酸化调节醛固酮的产生

Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T Breault, David Penton

A novel mouse model for an inducible gene modification in the renal thick ascending limb

肾粗升支可诱导基因修饰的新型小鼠模型

Laurent Bourqui, Denise V Winter, Alex Odermatt, Dominique Loffing-Cueni, Johannes Loffing

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

激素原转化酶 1/3 缺乏导致肥胖,这是由于胰岛素原处理受损所致

Daniel T Meier, Leila Rachid, Sophia J Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y Donath

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy

JAK和mTOR抑制剂可阻止细胞因子释放,同时保持T细胞双特异性抗体的体内疗效。

Gabrielle Leclercq ,Hélène Haegel ,Alberto Toso ,Tina Zimmermann ,Luke Green ,Nathalie Steinhoff ,Johannes Sam ,Vesna Pulko ,Anneliese Schneider ,Anna Maria Giusti ,John Challier ,Anne Freimoser-Grundschober ,Laurent Larivière ,Alex Odermatt ,Martin Stern ,Pablo Umana ,Marina Bacac ,Christian Klein

Androglobin, a chimeric mammalian globin, is required for male fertility

雄性珠蛋白是一种嵌合哺乳动物珠蛋白,是雄性生育能力所必需的。

Anna Keppner,Miguel Correia,Sara Santambrogio,Teng Wei Koay,Darko Maric,Carina Osterhof,Denise V Winter,Angèle Clerc,Michael Stumpe,Frédéric Chalmel,Sylvia Dewilde,Alex Odermatt,Dieter Kressler,Thomas Hankeln,Roland H Wenger,David Hoogewijs

Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters

对羟基苯甲酸酯和二苯甲酮紫外线吸收剂激活视黄酸相关孤儿受体 γ(t)

Silvia G Inderbinen, Manuel Kley, Michael Zogg, Manuel Sellner, André Fischer, Jacek Kędzierski, Stéphanie Boudon, Anton M Jetten, Martin Smieško, Alex Odermatt