EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
EGFR 介导的 MAPK 信号重新激活导致 BRAF 突变型结直肠癌对维莫非尼 RAF 抑制不敏感
期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-11-0341
Ryan B Corcoran, Hiromichi Ebi, Alexa B Turke, Erin M Coffee, Michiya Nishino, Alexandria P Cogdill, Ronald D Brown, Patricia Della Pelle, Dora Dias-Santagata, Kenneth E Hung, Keith T Flaherty, Adriano Piris, Jennifer A Wargo, Jeffrey Settleman, Mari Mino-Kenudson, Jeffrey A Engelman