日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Variety in the USP deubiquitinase catalytic mechanism

USP 去泛素化酶催化机制的多样性

Niels Keijzer, Anu Priyanka, Yvette Stijf-Bultsma, Alexander Fish, Malte Gersch, Titia K Sixma

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

出乎意料的举动:MutSα 的构象变化使其能够高亲和力地结合 DNA 错配。

Susanne R Bruekner,Wietske Pieters,Alexander Fish,A Manuel Liaci,Serge Scheffers,Emily Rayner,Daphne Kaldenbach,Lisa Drost,Marleen Dekker,Sandrine van Hees-Stuivenberg,Elly Delzenne-Goette,Charlotte de Konink,Hellen Houlleberghs,Hendrikus Jan Dubbink,Abeer AlSaegh,Niels de Wind,Friedrich Förster,Hein Te Riele,Titia K Sixma

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

靶向 CDT1/Geminin 蛋白复合物的小分子抑制剂促进癌细胞的 DNA 损伤和细胞死亡

Nikolaos Karantzelis, Michalis Petropoulos, Valeria De Marco, David A Egan, Alexander Fish, Evangelos Christodoulou, David W Will, Joe D Lewis, Anastassis Perrakis, Zoi Lygerou, Stavros Taraviras

Insert L1 is a central hub for allosteric regulation of USP1 activity

插入 L1 是 USP1 活性变构调节的中心枢纽

Shreya Dharadhar, Willem J van Dijk, Serge Scheffers, Alexander Fish, Titia K Sixma

Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation

自然杀伤细胞活化受体 NKp30 寡聚化依赖于其 N-糖基化

Ondřej Skořepa, Samuel Pazicky, Barbora Kalousková, Jan Bláha, Celeste Abreu, Tomáš Ječmen, Michal Rosůlek, Alexander Fish, Arthur Sedivy, Karl Harlos, Jan Dohnálek, Tereza Skálová, Ondřej Vaněk

Sharp kinking of a coiled-coil in MutS allows DNA binding and release

MutS 中卷曲螺旋的急剧扭结允许 DNA 结合和释放

Doreth Bhairosing-Kok, Flora S Groothuizen, Alexander Fish, Shreya Dharadhar, Herrie H K Winterwerp, Titia K Sixma

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

多步 USP7 机制动力学分析表明靶蛋白在活性中起着关键作用

Robbert Q Kim, Paul P Geurink, Monique P C Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen, Titia K Sixma0

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

动态动粒尺寸调节促进有丝分裂中的微管捕获和染色体生物定向

Carlos Sacristan, Misbha Ud Din Ahmad, Jenny Keller, Job Fermie, Vincent Groenewold, Eelco Tromer, Alexander Fish, Roberto Melero, José María Carazo, Judith Klumperman, Andrea Musacchio, Anastassis Perrakis, Geert Jpl Kops

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

USP48 通过位点特异性切割 BRCA1 泛素标记来抑制 H2A 切除

Michael Uckelmann, Ruth M Densham, Roy Baas, Herrie H K Winterwerp, Alexander Fish, Titia K Sixma, Joanna R Morris

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

针对 J 碱基结合蛋白 1 的骆驼衍生纳米抗体的表征和结构测定

Bart van Beusekom, Tatjana Heidebrecht, Athanassios Adamopoulos, Alexander Fish, Els Pardon, Jan Steyaert, Robbie P Joosten, Anastassis Perrakis