Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity
在丝氨酸 199 位点对异质性核糖核蛋白 A1 进行磷酸化替代，通过影响链退火消除 AKT 依赖性内部核糖体进入位点转录因子 (ITAF) 的功能，并导致哺乳动物对雷帕霉素靶蛋白复合物 1 (mTORC1) 抑制剂产生敏感性
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M110.205096
Jheralyn Martin, Janine Masri, Cheri Cloninger, Brent Holmes, Nicholas Artinian, Alexander Funk, Teresa Ruegg, Lauren Anderson, Tariq Bashir, Andrew Bernath, Alan Lichtenstein, Joseph Gera
