日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

通过改变干细胞RNA调控来获得对克隆性造血的遗传抵抗力

Gaurav Agarwal,Mateusz Antoszewski,Xueqin Xie,Yash Pershad,Uma P Arora,Chi-Lam Poon,Peng Lyu,Andrew J Lee,Chun-Jie Guo,Tianyi Ye,Laila Barakat Norford,Anna-Lena Neehus,Lucrezia Della Volpe,Lara Wahlster,Diyanath Ranasinghe,Tzu-Chieh Ho,Trevor S Barlowe,Arthur Chow,Alexandra Schurer,James Taggart,Benjamin H Durham,Omar Abdel-Wahab,Kathy L McGraw,James M Allan,Ruslan Soldatov,Alexander G Bick,Michael G Kharas,Vijay G Sankaran

Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis

端粒缩短成为衰老造血和白血病发生过程中克隆选择的工具

Matthew A McLoughlin #,Sruthi Cheloor Kovilakam #,William G Dunn #,Muxin Gu,Jake Tobin,Yash Pershad,Nicholas Williams,Daniel Leongamornlert,Kevin Dawson,Laura Bond,Ludovica Marando,Sean Wen,Rachael Wilson,Giampiero Valenzano,Vasiliki Symeonidou,Justyna Rak,Aristi Damaskou,Malgorzata Gozdecka,Xiaoxuan Liu,Clea Barcena,Josep Nomdedeu,Paul Costeas,Ioannis D Dimitriou,Edoardo Fiorillo,Valeria Orrù,Jose Guilherme de Almeida,Thomas McKerrell,Matthew Cullen,Irina Mohorianu,Theodora Foukaneli,Alan J Warren,Chi Wong,George Follows,Anna L Godfrey,Emma Gudgin,Francesco Cucca,Eoin McKinney,E Joanna Baxter,Moritz Gerstung,Jonathan Mitchell,Daniel Wiseman,Alexander G Bick,Margarete Fabre,Pedro M Quiros,Jyoti Nangalia,Siddhartha Kar,George S Vassiliou

Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation

CHIP 的全基因组 DNA 甲基化关联研究揭示了基因调控紊乱的机制。

Sara Kirmani # ,Tianxiao Huan # ,Joseph C Van Amburg ,Roby Joehanes ,Md Mesbah Uddin ,Ngoc Quynh H Nguyen ,Bing Yu ,Jennifer A Brody ,Myriam Fornage ,Jan Bressler ,Nona Sotoodehnia ,David A Ong ,Fabio Puddu ,James S Floyd ,Christie M Ballantyne ,Bruce M Psaty ,Laura M Raffield ,Pradeep Natarajan ,Karen N Conneely ,Joshua S Weinstock ,April P Carson ,Leslie A Lange ,Kendra Ferrier ,Nancy L Heard-Costa ,Joanne Murabito ,Alexander G Bick ,Daniel Levy

Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury

克隆性造血功能异常与急性肾损伤相关

Caitlyn Vlasschaert ,Cassianne Robinson-Cohen ,Jianchun Chen ,Elvis Akwo ,Alyssa C Parker ,Samuel A Silver ,Pavan K Bhatraju ,Hannah Poisner ,Shirong Cao ,Ming Jiang ,Yinqiu Wang ,Aolei Niu ,Edward Siew ,Joseph C Van Amburg ,Holly J Kramer ,Anna Kottgen ,Nora Franceschini ,Bruce M Psaty ,Russell P Tracy ,Alvaro Alonso ,Dan E Arking ,Josef Coresh ,Christie M Ballantyne ,Eric Boerwinkle ,Morgan Grams ,Ming-Zhi Zhang ,Bryan Kestenbaum ,Matthew B Lanktree ,Michael J Rauh ,Raymond C Harris Jr ,Alexander G Bick

Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure

髓系特异性JAK2参与炎症反应和血压盐敏感性。

Mohammad Saleem ,Luul A Aden ,Ashley L Mutchler ,Chitra Basu ,Lale A Ertuglu ,Quanhu Sheng ,Niki Penner ,Anna R Hemnes ,Jennifer H Park ,Jeanne A Ishimwe ,Cheryl L Laffer ,Fernando Elijovich, Celestine N Wanjalla ,Nestor de la Visitacion ,Paul D Kastner ,Claude F Albritton ,Taseer Ahmad ,Alexandria P Haynes ,Justin Yu ,Meghan K Graber ,Sharia Yasmin ,Kay-Uwe Wagner ,Peter P Sayeski ,Antonis K Hatzopoulos ,Eric R Gamazon ,Alexander G Bick ,Thomas R Kleyman ,Annet Kirabo

Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function

中性粒细胞介导的先天免疫对细菌性肺炎的抵抗力依赖于Tet2功能。

Candice Quin ,Erica N DeJong ,Elina K Cook ,Yi Zhen Luo ,Caitlyn Vlasschaert ,Sanathan Sadh ,Amy Jm McNaughton ,Marco M Buttigieg ,Jessica A Breznik ,Allison E Kennedy ,Kevin Zhao ,Jeffrey Mewburn ,Kimberly J Dunham-Snary ,Charles Ct Hindmarch ,Alexander G Bick ,Stephen L Archer ,Michael J Rauh ,Dawn Me Bowdish

Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation

人类克隆性造血的多组学分析揭示了基因型和细胞特异性炎症通路激活。

J Brett Heimlich ,Pawan Bhat ,Alyssa C Parker ,Matthew T Jenkins ,Caitlyn Vlasschaert ,Jessica Ulloa ,Joseph C Van Amburg ,Chad R Potts ,Sydney Olson ,Alexander J Silver ,Ayesha Ahmad ,Brian Sharber ,Donovan Brown ,Ningning Hu ,Peter van Galen ,Michael R Savona ,Alexander G Bick ,P Brent Ferrell

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

TCL1A的异常激活促进克隆性造血中的干细胞扩增

Joshua S Weinstock #,Jayakrishnan Gopakumar #,Bala Bharathi Burugula,Md Mesbah Uddin,Nikolaus Jahn,Julia A Belk,Hind Bouzid,Bence Daniel,Zhuang Miao,Nghi Ly,Taralynn M Mack,Sofia E Luna,Katherine P Prothro,Shaneice R Mitchell,Cecelia A Laurie,Lisa R Yanek,Lewis C Becker,Sharon L R Kardia,Patricia A Peyser,Jiang He,Michiel Rienstra,Pim Van der Harst,Robert Kaplan,Susan R Heckbert,Nicholas L Smith,Kerri L Wiggins,Donna K Arnett,Marguerite R Irvin,Hemant Tiwari,Michael J Cutler,Stacey Knight,J Brent Muhlestein,Adolfo Correa,Laura M Raffield,Yan Gao,Mariza de Andrade,Jerome I Rotter,Stephen S Rich,Russell P Tracy,Barbara A Konkle,Jill M Johnsen,Marsha M Wheeler,J Gustav Smith,Olle Melander,Peter M Nilsson,Brian S Custer,Ravindranath Duggirala,Joanne E Curran,John Blangero,Stephen McGarvey,L Keoki Williams,Shujie Xiao,Mao Yang,C Charles Gu,Yii-Der Ida Chen,Gregory M Marcus,John P Kane,Clive R Pullinger,M Benjamin Shoemaker,Dawood Darbar,Dan M Roden,Christine Albert,Charles Kooperberg,Ying Zhou,JoAnn E Manson,Pinkal Desai,Andrew D Johnson,Rasika A Mathias,Albert V Smith,Hyun M Kang,Ansuman T Satpathy,Pradeep Natarajan,Jacob O Kitzman,Eric A Whitsel,Alexander P Reiner,Alexander G Bick,Siddhartha Jaiswal

SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation

SRCAP突变通过表观遗传和DNA修复失调驱动克隆性造血

Chun-Wei Chen ,Linda Zhang ,Ravi Dutta ,Abhishek Niroula ,Peter G Miller ,Christopher J Gibson ,Alexander G Bick ,Jaime M Reyes ,Yi-Tang Lee ,Ayala Tovy ,Tianpeng Gu ,Sarah Waldvogel ,Yi-Hung Chen ,Bryan J Venters ,Pierre-Olivier Estève ,Sriharsa Pradhan ,Michael-Christopher Keogh ,Pradeep Natarajan ,Koichi Takahashi ,Adam S Sperling ,Margaret A Goodell

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk

炎症和克隆性造血相关心血管风险的基因修饰

Zhi Yu ,Trevor P Fidler ,Yunfeng Ruan ,Caitlyn Vlasschaert ,Tetsushi Nakao ,Md Mesbah Uddin ,Taralynn Mack ,Abhishek Niroula ,J Brett Heimlich ,Seyedeh M Zekavat ,Christopher J Gibson ,Gabriel K Griffin ,Yuxuan Wang ,Gina M Peloso ,Nancy Heard-Costa ,Daniel Levy ,Ramachandran S Vasan ,François Aguet ,Kristin G Ardlie ,Kent D Taylor ,Stephen S Rich ,Jerome I Rotter ,Peter Libby ,Siddhartha Jaiswal ,Benjamin L Ebert ,Alexander G Bick ,Alan R Tall ,Pradeep Natarajan