日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the Tryptophan(6.48) "Toggle Switch"

色氨酸(6.48)“切换开关”对神经肽Y1 G蛋白偶联受体的微调

Voitel, Matthias; Pankonin, Maik; Vogel, Alexander; Leitner, Karl; Kaiser, Anette; Huster, Daniel; Hildebrand, Peter W; Smith, Albert A

The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity

对TRIM25 RNA结合机制的分子解析为其抗病毒活性提供了关键见解。

Lucía Álvarez # ,Kevin Haubrich # ,Louisa Iselin ,Laurent Gillioz ,Vincenzo Ruscica ,Karine Lapouge ,Sandra Augsten ,Ina Huppertz ,Nila Roy Choudhury ,Bernd Simon ,Pawel Masiewicz ,Mathilde Lethier ,Stephen Cusack ,Katrin Rittinger ,Frank Gabel ,Alexander Leitner ,Gracjan Michlewski ,Matthias W Hentze ,Frédéric H T Allain ,Alfredo Castello ,Janosch Hennig

A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle

ATP 驱动折叠循环过程中 PhLP2A 分子伴侣 TRiC 样磷化蛋白合作的结构图

Junsun Park #, Hyunmin Kim #, Daniel Gestaut #, Seyeon Lim, Kwadwo A Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung-Hun Roh

Stoichiometry and architecture of the human pyruvate dehydrogenase complex

人类丙酮酸脱氢酶复合物的化学计量和结构

Rafal Zdanowicz, Pavel Afanasyev, Adam Pruška, Julian A Harrison, Christoph Giese, Daniel Boehringer, Alexander Leitner, Renato Zenobi, Rudi Glockshuber

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

通过低温电子显微镜和结构蛋白质组学揭示 CaM 敏感的腺苷酸环化酶 AC8 的调控位点

Basavraj Khanppnavar #, Dina Schuster #, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov

A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2

采用混合结构测定方法研究 SARS-CoV-2 核衣壳蛋白的药物可利用性

Giacomo Padroni, Maria Bikaki, Mihajlo Novakovic, Antje C Wolter, Simon H Rüdisser, Alvar D Gossert, Alexander Leitner, Frederic H-T Allain

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

CIP2A抑制PP2A-B56α及其致癌性的结构机制

Karolina Pavic ,Nikhil Gupta # ,Judit Domènech Omella # ,Rita Derua ,Anna Aakula ,Riikka Huhtaniemi ,Juha A Määttä ,Nico Höfflin ,Juha Okkeri ,Zhizhi Wang ,Otto Kauko ,Roosa Varjus ,Henrik Honkanen ,Daniel Abankwa ,Maja Köhn ,Vesa P Hytönen ,Wenqing Xu ,Jakob Nilsson ,Rebecca Page ,Veerle Janssens ,Alexander Leitner ,Jukka Westermarck

A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT

分层组装途径指导 TRiC/CCT 的独特亚基排列

Karen Betancourt Moreira, Miranda P Collier, Alexander Leitner, Kathy H Li, Ivana L Serrano Lachapel, Frank McCarthy, Kwadwo A Opoku-Nsiah, Fabián Morales-Polanco, Natália Barbosa, Daniel Gestaut, Rahul S Samant, Soung-Hun Roh, Judith Frydman

Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase

霍乱弧菌 NADH:醌氧化还原酶中氧化还原驱动的 Na+ 易位的构象耦合

Jann-Louis Hau, Susann Kaltwasser, Valentin Muras, Marco S Casutt, Georg Vohl, Björn Claußen, Wojtek Steffen, Alexander Leitner, Eckhard Bill, George E Cutsail 3rd, Serena DeBeer, Janet Vonck, Julia Steuber, Günter Fritz

ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

ROS 诱导靶向 NRAS 突变黑色素瘤中代谢活性较低的持续癌细胞

Ossia M Eichhoff, Corinne I Stoffel, Jan Käsler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil F Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pål Johansen, Rebekka Wegmann, Julien Mena, Alaa