日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects

Acasunlimab 是一种 Fc 惰性 PD-L1×4-1BB 双特异性抗体,与 PD-1 阻断剂联合使用可通过互补的免疫调节作用增强抗肿瘤免疫力。

Michela Capello # ,Angelica Sette # ,Theo Plantinga ,Craig J Thalhauser ,Vanessa M Spires ,Kristina B Nürmberger ,Jordan M Blum ,Brandon W Higgs ,Patricia Garrido Castro ,Christina Yu ,Carol Costa Sa ,Sina Fellermeier-Kopf ,Saskia M Burm ,Kristin Strumane ,Aras Toker ,Andrea Imle ,Bruna de Andrade Pereira ,Alexander Muik ,Tahamtan Ahmadi ,Özlem Türeci ,Mark Fereshteh ,Ugur Sahin ,Maria Jure-Kunkel ,Nora Pencheva

A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade

一种经六聚化增强、Fc沉默的激动性CD27抗体,可作为单药或与PD-1阻断剂联合使用,增强T细胞效应功能。

Işıl Altıntaş ,Kristina B Nürmberger ,Andrea Imle ,Anna-Lena Krause ,Marike M van Beuge ,Aras Toker ,Andreea Ioan-Facsinay ,Jordan Blum ,Alexander Muik ,Frank J Beurskens ,Rob N de Jong ,David P E Satijn ,Friederike Gieseke ,Bart-Jan de Kreuk ,Maarten van der Kroef ,Sina Fellermeier-Kopf ,Tahamtan Ahmadi ,Özlem Türeci ,Esther C W Breij ,Uğur Şahin

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

COVID-19 疫苗 BNT162b1 可引发人类抗体和 TH1 T 细胞反应

Ugur Sahin, Alexander Muik, Evelyna Derhovanessian, Isabel Vogler, Lena M Kranz, Mathias Vormehr, Alina Baum, Kristen Pascal, Jasmin Quandt, Daniel Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Rolf Hilker, Dirk Becker, Ann-Kathrin Eller, Jan Grützner, Carsten Boesler, Corinna Rosen

Early computational detection of potential high-risk SARS-CoV-2 variants

早期计算检测潜在的高风险 SARS-CoV-2 变体

Karim Beguir, Marcin J Skwark, Yunguan Fu, Thomas Pierrot, Nicolas Lopez Carranza, Alexandre Laterre, Ibtissem Kadri, Abir Korched, Anna U Lowegard, Bonny Gaby Lui, Bianca Sänger, Yunpeng Liu, Asaf Poran, Alexander Muik, Uğur Şahin

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

针对晚期难治性实体瘤患者的靶向PD-L1和4-1BB的双特异性抗体(GEN1046)的临床前特征和I期试验结果

Alexander Muik,Elena Garralda,Isil Altintas,Friederike Gieseke,Ravit Geva,Eytan Ben-Ami,Corinne Maurice-Dror,Emiliano Calvo,Patricia M LoRusso,Guzman Alonso,Maria E Rodriguez-Ruiz,Kristina B Schoedel,Jordan M Blum,Bianca Sänger,Theodora W Salcedo,Saskia M Burm,Eliana Stanganello,Dennis Verzijl,Fulvia Vascotto,Angelica Sette,Juliane Quinkhardt,Theo S Plantinga,Aras Toker,Edward N van den Brink,Mark Fereshteh,Mustafa Diken,David Satijn,Sebastian Kreiter,Esther C W Breij,Gaurav Bajaj,Eleni Lagkadinou,Kate Sasser,Özlem Türeci,Ulf Forssmann,Tahamtan Ahmadi,Uğur Şahin #,Maria Jure-Kunkel #,Ignacio Melero #

Neutralization and durability of 2 or 3 doses of the BNT162b2 vaccine against Omicron SARS-CoV-2

或 3 剂 BNT162b2 疫苗对 Omicron SARS-CoV-2 的中和作用和持久性

Hongjie Xia, Jing Zou, Chaitanya Kurhade, Hui Cai, Qi Yang, Mark Cutler, David Cooper, Alexander Muik, Kathrin U Jansen, Xuping Xie, Kena A Swanson, Pei-Yong Shi

Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice

接触 BA.4/5 S 蛋白会导致接种过疫苗的人类和小鼠中 Omicron BA.1、BA.2、BA.2.12.1 和 BA.4/5 被中和

Alexander Muik, Bonny Gaby Lui, Maren Bacher, Ann-Kathrin Wallisch, Aras Toker, Carla Iris Cadima Couto, Alptekin Güler, Veena Mampilli, Geneva J Schmitt, Jonathan Mottl, Thomas Ziegenhals, Stephanie Fesser, Jonas Reinholz, Florian Wernig, Karla-Gerlinde Schraut, Hossam Hefesha, Hui Cai, Qi Yang, Ke

Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes

Omicron BA.1突破性感染驱动针对保守表位的交叉变异中和和记忆B细胞形成

Jasmin Quandt ,Alexander Muik ,Nadine Salisch ,Bonny Gaby Lui ,Sebastian Lutz ,Kimberly Krüger ,Ann-Kathrin Wallisch ,Petra Adams-Quack ,Maren Bacher ,Andrew Finlayson ,Orkun Ozhelvaci ,Isabel Vogler ,Katharina Grikscheit ,Sebastian Hoehl ,Udo Goetsch ,Sandra Ciesek ,Özlem Türeci ,Ugur Sahin

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

Omicron BA.2 突破性感染增强了 BA.2.12.1 和 BA.4/BA.5 的交叉中和作用

Alexander Muik, Bonny Gaby Lui, Maren Bacher, Ann-Kathrin Wallisch, Aras Toker, Andrew Finlayson, Kimberly Krüger, Orkun Ozhelvaci, Katharina Grikscheit, Sebastian Hoehl, Sandra Ciesek, Özlem Türeci, Ugur Sahin

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

DuoBody-CD40x4-1BB 通过条件性 CD40 和 4-1BB 激动剂活性诱导树突状细胞成熟并增强 T 细胞活化。

Alexander Muik ,Homer C Adams 3rd ,Friederike Gieseke ,Isil Altintas ,Kristina B Schoedel ,Jordan M Blum ,Bianca Sänger ,Saskia M Burm ,Eliana Stanganello ,Dennis Verzijl ,Vanessa M Spires ,Fulvia Vascotto ,Aras Toker ,Juliane Quinkhardt ,Mark Fereshteh ,Mustafa Diken ,David P E Satijn ,Sebastian Kreiter ,Tahamtan Ahmadi ,Esther C W Breij ,Özlem Türeci ,Kate Sasser ,Ugur Sahin ,Maria Jure-Kunkel