日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition

药物研发进展:整合 CADD 工具和药物再利用以抑制 PD-1/PD-L1 轴

Patrícia S Sobral, Tiago Carvalho, Shiva Izadi, Alexandra Castilho, Zélia Silva, Paula A Videira, Florbela Pereira

Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding

植物衍生的 Durvalumab 变体表现出有效的 PD-1/PD-L1 阻断和治疗上有利的 FcR 结合

Shiva Izadi, Simon Gumpelmair, Pedro Coelho, Henrique O Duarte, Joana Gomes, Judith Leitner, Vinny Kunnummel, Lukas Mach, Celso A Reis, Peter Steinberger, Alexandra Castilho

Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents

工程改造的可溶性三聚化 4-1BBL 变体作为有效的免疫调节剂

Claire Battin #, Annika De Sousa Linhares #, Judith Leitner, Anna Grossmann, Daniela Lupinek, Shiva Izadi, Alexandra Castilho, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Jochen Stritzker, Peter Steinberger

In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc

植物去糖基化可提高重组 ACE2-Fc 的 SARS-CoV-2 中和活性

Shiva Izadi, Ulrike Vavra, Stanislav Melnik, Clemens Grünwald-Gruber, Esther Föderl-Höbenreich, Markus Sack, Kurt Zatloukal, Josef Glössl, Eva Stöger, Lukas Mach, Alexandra Castilho, Richard Strasser

The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation

烟草 GNTI 茎区含有一个强同源蛋白复合物形成的基序

Jennifer Schoberer, Shiva Izadi, Carolina Kierein, Ulrike Vavra, Julia König-Beihammer, Valentina Ruocco, Clemens Grünwald-Gruber, Alexandra Castilho, Richard Strasser

Comparative analysis of plant transient expression vectors for targeted N-glycosylation

针对 N-糖基化的植物瞬时表达载体的比较分析

Lukas Eidenberger, Florian Eminger, Alexandra Castilho, Herta Steinkellner

The Instability of Dimeric Fc-Fusions Expressed in Plants Can Be Solved by Monomeric Fc Technology

单体 Fc 技术可解决植物中表达的二聚 Fc 融合蛋白的不稳定性

Pia Gattinger, Shiva Izadi, Clemens Grünwald-Gruber, Somanath Kallolimath, Alexandra Castilho

Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana

在糖工程化的本氏烟中生成具有酶活性的 SARS-CoV-2 诱饵受体 ACE2-Fc

Alexandra Castilho, Jennifer Schwestka, Nikolaus F Kienzl, Ulrike Vavra, Clemens Grünwald-Gruber, Shiva Izadi, Chaitra Hiremath, Janine Niederhöfer, Elisabeth Laurent, Vanessa Monteil, Ali Mirazimi, Gerald Wirnsberger, Johannes Stadlmann, Eva Stöger, Lukas Mach, Richard Strasser

Identification of two subtilisin-like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana

鉴定两种参与本氏烟重组蛋白降解的枯草杆菌蛋白酶样丝氨酸蛋白酶

Alejandro A Puchol Tarazona, Daniel Maresch, Annette Grill, Janet Bakalarz, Juan A Torres Acosta, Alexandra Castilho, Herta Steinkellner, Lukas Mach

Engineering the interactions between a plant-produced HIV antibody and human Fc receptors

设计植物产生的 HIV 抗体与人类 Fc 受体之间的相互作用

Szymon Stelter, Mathew J Paul, Audrey Y-H Teh, Melanie Grandits, Friedrich Altmann, Jessica Vanier, Muriel Bardor, Alexandra Castilho, Rachel Louise Allen, Julian K-C Ma