日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

LXR激动剂可改善Tau蛋白和ApoE4相关的胶质细胞脂质积累和神经退行性变

Alexandra Litvinchuk ,Jung H Suh ,Jing L Guo ,Karin Lin ,Sonnet S Davis ,Nga Bien-Ly ,Eric Tycksen ,G Travis Tabor ,Javier Remolina Serrano ,Melissa Manis ,Xin Bao ,Choonghee Lee ,Megan Bosch ,Enmanuel J Perez ,Carla M Yuede ,Anil G Cashikar ,Jason D Ulrich ,Gilbert Di Paolo ,David M Holtzman

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

内皮细胞C3a受体介导衰老过程中的血管炎症和血脑屏障通透性

Nicholas E Propson ,Ethan R Roy ,Alexandra Litvinchuk ,Jörg Köhl ,Hui Zheng

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

利用反义寡核苷酸降低载脂蛋白E4水平可减轻tau蛋白病模型中的神经退行性变

Alexandra Litvinchuk ,Tien-Phat V Huynh ,Yang Shi ,Rosemary J Jackson ,Mary B Finn ,Melissa Manis ,Caroline M Francis ,Ainsley C Tran ,Patrick M Sullivan ,Jason D Ulrich ,Bradley T Hyman ,Tracy Cole ,David M Holtzman

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease

补体 C3aR 失活可减弱 Tau 病理并逆转 Tau 病变模型和阿尔茨海默病中失调的免疫网络

Alexandra Litvinchuk, Ying-Wooi Wan, Dan B Swartzlander, Fading Chen, Allysa Cole, Nicholas E Propson, Qian Wang, Bin Zhang, Zhandong Liu, Hui Zheng

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

星形胶质细胞-小胶质细胞通过补体激活进行串扰调节阿尔茨海默病小鼠模型中的淀粉样蛋白病理

Hong Lian, Alexandra Litvinchuk, Angie C-A Chiang, Nadia Aithmitti, Joanna L Jankowsky, Hui Zheng

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

天然相互作用蛋白可支撑并稳定 SCA1 中的有毒 ATAXIN-1 寡聚体

Cristian A Lasagna-Reeves, Maxime Wc Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi