Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency
胞苷类似物由于MBD4缺陷导致碱基切除修复功能障碍,从而具有合成致死性。
期刊:npj Precision Oncology
影响因子:6.8
doi:10.1038/s41698-022-00326-z
Thomas Chabot ,Fariba Nemati ,Aurélie Herbette ,Alexandre Demeyer ,Stéphane Dayot ,Olivier Ganier ,Samar Alsafadi ,Sophie Gardrat ,Pascale Mariani ,Marie Luporsi ,Maxime Corbé ,Vincent Servois ,Nathalie Cassoux ,Didier Decaudin ,Sergio Roman Roman ,Elaine Del Nery ,Sophie Piperno-Neumann ,Marc-Henri Stern ,Manuel Rodrigues