日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

SAR439459 抑制泛 TGFβ 可缓解免疫抑制并提高 PD-1 阻断的抗肿瘤功效

Rita Greco, Hongjing Qu, Hui Qu, Joachim Theilhaber, Gary Shapiro, Richard Gregory, Christopher Winter, Natalia Malkova, Frank Sun, Julie Jaworski, Annie Best, Lily Pao, Andrew Hebert, Mikhail Levit, Alexei Protopopov, Jack Pollard, Keith Bahjat, Dmitri Wiederschain, Sharad Sharma

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

染色体和染色体外 DNA 元素的不一致遗传导致胶质母细胞瘤的动态疾病演变

Ana C deCarvalho #, Hoon Kim #, Laila M Poisson, Mary E Winn, Claudius Mueller, David Cherba, Julie Koeman, Sahil Seth, Alexei Protopopov, Michelle Felicella, Siyuan Zheng, Asha Multani, Yongying Jiang, Jianhua Zhang, Do-Hyun Nam, Emanuel F Petricoin, Lynda Chin, Tom Mikkelsen, Roel G W Verhaak

PRKCI promotes immune suppression in ovarian cancer

PRKCI促进卵巢癌的免疫抑制

Sharmistha Sarkar ,Christopher A Bristow ,Prasenjit Dey ,Kunal Rai ,Ruth Perets ,Alejandra Ramirez-Cardenas ,Shruti Malasi ,Emmet Huang-Hobbs ,Monika Haemmerle ,Sherry Y Wu ,Michael McGuire ,Alexei Protopopov ,Shan Jiang ,Joyce F Liu ,Michelle S Hirsch ,Qing Chang ,Alexander J Lazar ,Anil K Sood ,Ronny Drapkin ,Ronald DePinho ,Giulio Draetta ,Lynda Chin

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

联合临床评估确定了黑色素瘤中 BRAF 抑制剂耐药的模式

Lawrence N Kwong, Genevieve M Boland, Dennie T Frederick, Timothy L Helms, Ahmad T Akid, John P Miller, Shan Jiang, Zachary A Cooper, Xingzhi Song, Sahil Seth, Jennifer Kamara, Alexei Protopopov, Gordon B Mills, Keith T Flaherty, Jennifer A Wargo, Lynda Chin

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

SMARCA2/4 ATPase 结构域在 SWI/SNF 突变癌症中作为药物靶标的作用优于溴结构域:来自 cDNA 拯救和 PFI-3 抑制剂研究的见解

Bhavatarini Vangamudi, Thomas A Paul #, Parantu K Shah #, Maria Kost-Alimova, Lisa Nottebaum, Xi Shi, Yanai Zhan, Elisabetta Leo, Harshad S Mahadeshwar, Alexei Protopopov, Andrew Futreal, Trang N Tieu, Mike Peoples, Timothy P Heffernan, Joseph R Marszalek, Carlo Toniatti, Alessia Petrocchi, Dominiqu

Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer

在胰腺癌患者血清外泌体中鉴定出跨越所有染色体的双链基因组DNA,该DNA含有突变的KRAS和p53 DNA

Christoph Kahlert ,Sonia A Melo, Alexei Protopopov, Jiabin Tang, Sahil Seth, Moritz Koch, Jianhua Zhang, Juergen Weitz, Lynda Chin, Andrew Futreal, Raghu Kalluri

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

骨髓微环境中造血干细胞和祖细胞定位和缺氧状态的定量成像

César Nombela-Arrieta, Gregory Pivarnik, Beatrice Winkel, Kimberly J Canty, Brendan Harley, John E Mahoney, Shin-Young Park, Jiayun Lu, Alexei Protopopov, Leslie E Silberstein

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy

端粒功能障碍在杜氏肌营养不良症心力衰竭中的作用

Foteini Mourkioti, Jackie Kustan, Peggy Kraft, John W Day, Ming-Ming Zhao, Maria Kost-Alimova, Alexei Protopopov, Ronald A DePinho, Daniel Bernstein, Alan K Meeker, Helen M Blau

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

PTEN 是胰腺导管腺癌的主要肿瘤抑制因子,并调节 NF-κB 细胞因子网络

Haoqiang Ying, Kutlu G Elpek, Anant Vinjamoori, Stephanie M Zimmerman, Gerald C Chu, Haiyan Yan, Eliot Fletcher-Sananikone, Hailei Zhang, Yingchun Liu, Wei Wang, Xiaojia Ren, Hongwu Zheng, Alec C Kimmelman, Ji-hye Paik, Carol Lim, Samuel R Perry, Shan Jiang, Brian Malinn, Alexei Protopopov, Simona C

Cloning and Initial Functional Characterization of Mlk4α and Mlk4β

Mlk4α 和 Mlk4β 的克隆和初步功能表征

Vladimir I Kashuba, Elvira V Grigorieva, Sergei M Kvasha, Tatiana V Pavlova, Vladimir Grigoriev, Alexei Protopopov, Olga Kharchenko, Rinat Gizatullin, Alla V Rynditch, Eugene R Zabarovsky