日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells

选择性和脑渗透性 ACSS2 抑制剂靶向乳腺癌脑转移细胞

Emily M Esquea, Lorela Ciraku, Riley G Young, Jessica Merzy, Alexandra N Talarico, Nusaiba N Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V Crispim, Adel A Rashad, Simon Cocklin, Nathaniel W Snyder, Joris Beld, Nicole L Simone, Mauricio J Reginato, Alexej Dick

ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells

ACSS2 以 E2F1 依赖的方式调控乳腺癌脑转移细胞中的铁死亡

Emily M Esquea, Riley G Young, Lorela Ciraku, Jessica Merzy, Nusaiba N Ahmed, Alexandra N Talarico, Mangalam Karuppiah, Wiktoria Gocal, Nicole L Simone, Alexej Dick, Mauricio J Reginato

Copper Modulates the Catalytic Activity of Protein Kinase CK2

铜调节蛋白激酶 CK2 的催化活性

John E Chojnowski, Rongrong Li, Tiffany Tsang, Fatimah H Alfaran, Alexej Dick, Simon Cocklin, Donita C Brady, Todd I Strochlic

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

使用多步计算工作流程快速优化人类免疫缺陷病毒 1 型衣壳抑制剂的代谢稳定性

Megan E Meuser, Poli Adi Narayana Reddy, Alexej Dick, Jean Marc Maurancy, Joseph M Salvino, Simon Cocklin

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

改变环境构象动力学作为对肽三唑 HIV-1 灭活剂产生抗性的机制

Shiyu Zhang #, Andrew P Holmes #, Alexej Dick, Adel A Rashad, Lucía Enríquez Rodríguez, Gabriela A Canziani, Michael J Root, Irwin M Chaiken

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

新型 RAD51 抑制剂靶向人类细胞中的同源重组

Irina S Shkundina, Alexander A Gall, Alexej Dick, Simon Cocklin, Alexander V Mazin

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

含苯磺酰胺的苯丙氨酸衍生物作为新型HIV-1衣壳抑制剂的设计、合成及机理研究及其抗病毒活性的提高

Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Kuo-Hsiung Lee, Xinyong Liu, Peng Zhan

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

4-苯基-1H-1,2,3-三唑苯丙氨酸衍生物的设计、合成及构效关系,作为具有良好抗病毒活性的新型 HIV-1 衣壳抑制剂

Lin Sun, Tianguang Huang, Alexej Dick, Megan E Meuser, Waleed A Zalloum, Chin-Ho Chen, Xiao Ding, Ping Gao, Simon Cocklin, Kuo-Hsiung Lee, Peng Zhan, Xinyong Liu

Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors

亚稳态HIV-1表面蛋白Env使细胞膜对双效杀病毒进入抑制剂的转化和穿孔作用更加敏感

Charles G Ang,Md Alamgir Hossain,Marg Rajpara,Harry Bach,Kriti Acharya,Alexej Dick,Adel A Rashad,Michele Kutzler,Cameron F Abrams,Irwin Chaiken

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

基于场的新型氮杂双环己烷支架 HIV-1 进入抑制剂的亲和力优化

Megan E Meuser, Adel A Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B Ward, Simon Cocklin