Alexis Digman相关文献与解析，生知库 | 链接生命科学的每一步

Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

星形胶质细胞阴阳 1 对小鼠大脑发育和防止细胞凋亡、氧化应激和炎症至关重要

Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Cynthia Vied, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Lee

信号转导

The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction

小胶质细胞 LRRK2 激酶通过 NLRP3 炎症小体和 RAB10 介导的自噬功能障碍在锰诱导的炎症神经毒性中的作用

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2023.104879

Edward Pajarillo, Sanghoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Lee

Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice

纹状体星形胶质细胞中 RE1 沉默转录因子的删除加剧了小鼠锰诱导的神经毒性

期刊:Glia

影响因子:5.4

doi:10.1002/glia.24226

Edward Pajarillo, Mark Demayo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Michael Aschner, Eunsook Lee

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

星形胶质细胞转录因子 REST 上调谷氨酸转运蛋白 EAAT2，保护多巴胺能神经元免受锰诱导的兴奋毒性

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2021.101372

Edward Pajarillo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Karam F A Soliman, Michael Aschner, Eunsook Lee

Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro

锰诱导的活性氧激活 IκB 激酶，上调 YY1 并损害人类星形胶质细胞中的谷氨酸转运蛋白 EAAT2 功能

期刊:Neurotoxicology

影响因子:3.4

doi:10.1016/j.neuro.2021.07.004

Asha Rizor, Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Leyah Mooneyham, Deok-Soo Son, Michael Aschner, Eunsook Lee

Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice

多巴胺能 REST/NRSF 可保护小鼠免受锰诱导的神经毒性

Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

星形胶质细胞阴阳 1 对小鼠大脑发育和防止细胞凋亡、氧化应激和炎症至关重要

The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction

小胶质细胞 LRRK2 激酶通过 NLRP3 炎症小体和 RAB10 介导的自噬功能障碍在锰诱导的炎症神经毒性中的作用

Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice

纹状体星形胶质细胞中 RE1 沉默转录因子的删除加剧了小鼠锰诱导的神经毒性

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

星形胶质细胞转录因子 REST 上调谷氨酸转运蛋白 EAAT2，保护多巴胺能神经元免受锰诱导的兴奋毒性

Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro

锰诱导的活性氧激活 IκB 激酶，上调 YY1 并损害人类星形胶质细胞中的谷氨酸转运蛋白 EAAT2 功能