日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques

重组人单克隆抗体的治疗性给药可降低恒河猴基孔肯雅病毒病的严重程度

Rebecca Broeckel, Julie M Fox, Nicole Haese, Craig N Kreklywich, Soila Sukulpovi-Petty, Alfred Legasse, Patricia P Smith, Michael Denton, Carsten Corvey, Shiv Krishnan, Lois M A Colgin, Rebecca M Ducore, Anne D Lewis, Michael K Axthelm, Marie Mandron, Pierre Cortez, Jonathan Rothblatt, Ercole Rao, I

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

从持续感染的狒狒身上分离出的猿猴出血热病毒可有效诱发日本猕猴出血热疾病

Heather A Vatter, Eric F Donaldson, Jeremy Huynh, Stephanie Rawlings, Minsha Manoharan, Alfred Legasse, Shannon Planer, Mary F Dickerson, Anne D Lewis, Lois M A Colgin, Michael K Axthelm, Jerilyn K Pecotte, Ralph S Baric, Scott W Wong, Margo A Brinton

T cell inactivation by poxviral B22 family proteins increases viral virulence

痘病毒 B22 家族蛋白使 T 细胞失活,从而增强病毒毒力

Dina Alzhanova, Erika Hammarlund, Jason Reed, Erin Meermeier, Stephanie Rawlings, Caroline A Ray, David M Edwards, Ben Bimber, Alfred Legasse, Shannon Planer, Jerald Sprague, Michael K Axthelm, David J Pickup, David M Lewinsohn, Marielle C Gold, Scott W Wong, Jonah B Sacha, Mark K Slifka, Klaus Früh

Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection

在进行性猿猴免疫缺陷病毒感染中,幼稚 T 细胞对于记忆性 CD4+ T 细胞稳态而言是可有可无的

Afam A Okoye, Mukta Rohankhedkar, Chike Abana, Audrie Pattenn, Matthew Reyes, Christopher Pexton, Richard Lum, Andrew Sylwester, Shannon L Planer, Alfred Legasse, Byung S Park, Michael Piatak Jr, Jeffrey D Lifson, Michael K Axthelm, Louis J Picker

Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection

猴痘病毒补体酶抑制剂基因座的缺失会影响非人类灵长类动物感染模型对猴痘病毒的适应性免疫反应

Ryan D Estep, Ilhem Messaoudi, Megan A O'Connor, Helen Li, Jerald Sprague, Alexander Barron, Flora Engelmann, Bonnie Yen, Michael F Powers, John M Jones, Bridget A Robinson, Beata U Orzechowska, Minsha Manoharan, Alfred Legasse, Shannon Planer, Jennifer Wilk, Michael K Axthelm, Scott W Wong

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

幼稚 T 细胞的丢失和细胞库的收缩预示着老年灵长类动物对疫苗接种的反应不佳

Luka Cicin-Sain, Susan Smyk-Pearson, Noreen Currier, Laura Byrd, Caroline Koudelka, Tammie Robinson, Gwendolyn Swarbrick, Shane Tackitt, Alfred Legasse, Miranda Fischer, Dragana Nikolich-Zugich, Byung Park, Theodore Hobbs, Cynthia J Doane, Motomi Mori, Michael K Axthelm, Deborah A Lewinsohn, Janko N

Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection

慢性 SIV 感染中 CD4+ 中央记忆 T 细胞逐渐减少,导致 CD4+ 效应记忆功能不足和明显疾病

Afam Okoye, Martin Meier-Schellersheim, Jason M Brenchley, Shoko I Hagen, Joshua M Walker, Mukta Rohankhedkar, Richard Lum, John B Edgar, Shannon L Planer, Alfred Legasse, Andrew W Sylwester, Michael Piatak Jr, Jeffrey D Lifson, Vernon C Maino, Donald L Sodora, Daniel C Douek, Michael K Axthelm, Zvi