Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication
多个β冠状病毒宏结构域2环中高度保守的异亮氨酸残基的突变表明,增强的ADP-核糖结合不利于病毒复制。
期刊:Journal of Virology
影响因子:3.8
doi:10.1128/jvi.01313-24
Kerr, Catherine M; Pfannenstiel, Jessica J; Alhammad, Yousef M; O'Connor, Joseph J; Ghimire, Roshan; Shrestha, Rakshya; Khattabi, Reem; Saenjamsai, Pradtahna; Parthasarathy, Srivatsan; McDonald, Peter R; Gao, Philip; Johnson, David K; More, Sunil; Roy, Anuradha; Channappanavar, Rudragouda; Fehr, Anthony R