日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

功能丧失的 PCSK9Q152H 变体可增加 ER 伴侣 GRP78 和 GRP94,并防止肝损伤

Paul F Lebeau, Hanny Wassef, Jae Hyun Byun, Khrystyna Platko, Brandon Ason, Simon Jackson, Joshua Dobroff, Susan Shetterly, William G Richards, Ali A Al-Hashimi, Kevin Doyoon Won, Majambu Mbikay, Annik Prat, An Tang, Guillaume Paré, Renata Pasqualini, Nabil G Seidah, Wadih Arap, Michel Chrétien, Ric

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions

抗GRP78自身抗体诱导内皮细胞活化并加速动脉粥样硬化病变的发展

Elizabeth D Crane, Ali A Al-Hashimi, Jack Chen, Edward G Lynn, Kevin Doyoon Won, Šárka Lhoták, Magda Naeim, Khrystyna Platko, Paul Lebeau, Jae Hyun Byun, Bobby Shayegan, Joan C Krepinsky, Katey J Rayner, Serena Marchiò, Renata Pasqualini, Wadih Arap, Richard C Austin

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

功能丧失的 PCSK9 突变体逃避未折叠蛋白反应传感器 GRP78,并且在保留时无法诱导内质网应激

Paul Lebeau, Khrystyna Platko, Ali A Al-Hashimi, Jae Hyun Byun, Šárka Lhoták, Nicholas Holzapfel, Gabriel Gyulay, Suleiman A Igdoura, David R Cool, Bernardo Trigatti, Nabil G Seidah, Richard C Austin

Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor

针对细胞表面相关分子伴侣 GRP78 的自身抗体通过组织因子刺激肿瘤生长

Ali A Al-Hashimi, Paul Lebeau, Fadwa Majeed, Enio Polena, Šárka Lhotak, Celeste A F Collins, Jehonathan H Pinthus, Mario Gonzalez-Gronow, Jen Hoogenes, Salvatore V Pizzo, Mark Crowther, Anil Kapoor, Janusz Rak, Gabriel Gyulay, Sara D'Angelo, Serena Marchiò, Renata Pasqualini, Wadih Arap, Bobby Shaye

Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores

抗 GRP78 自身抗体与细胞表面结合,GRP78 通过释放内质网库中的钙离子来增加组织因子促凝活性

Ali A Al-Hashimi, Jennifer Caldwell, Mario Gonzalez-Gronow, Salvatore V Pizzo, Danya Aboumrad, Lindsay Pozza, Hiam Al-Bayati, Jeffrey I Weitz, Alan Stafford, Howard Chan, Anil Kapoor, Donald W Jacobsen, Jeffrey G Dickhout, Richard C Austin