日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway.

Globo H 神经酰胺通过 A2AR/cAMP/PKA 通路赋予晚期胆囊癌化疗耐药性和不良预后。

期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.126092
Hung Tsai-Hsien, Hung Jung-Tung, Huang Wen-Kuan, Huang Yenlin, Wu Chiao-En, Cheng Jing-Yan, Lee Chien-Wei, Yu John, Wu Yi-Chia, Yeh Chun-Nan, Yu Alice L
胆囊癌
神经科学
PKA
CAMP
发表日期：2026
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Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes

基础胰岛素分泌决定了1型糖尿病1期患者对阿巴西普的反应

期刊:Diabetes
影响因子:7.5
doi:10.2337/db25-0801
Galderisi, Alfonso; Carr, Alice L J; Taylor, Peter; Bonet, Jacopo; Cuthbertson, David; Sosenko, Jay; Sims, Emily K; Evans-Molina, Carmella; Dalla Man, Chiara; Ismail, Heba M; Nathan, Brandon; Petrelli, Alessandra; Senior, Peter; Sherr, Jennifer L; Herold, Kevan C; Russell, William E; Moran, Antoinette; Dayan, Colin
代谢
糖尿病
免疫/内分泌
发表日期：2026
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Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2

药物再利用：将外周限制性 HIV 蛋白酶抑制剂安普那韦转化为强效、选择性强且能穿透血脑屏障的大麻素受体 2 激动剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02796
Haymer, Daniel H; Duncan, Renn A; Rodriguez, Alice L; Han, Allie; Lindsay, Richard J; Wijesiri, N Kithmini; Thompson Gray, Analisa; Krishnan, Srinivasan; Qi, Aidong; Brown, Benjamin P; Boutaud, Olivier; Engers, Darren W; Jones, Carrie K; Niswender, Colleen M; Lindsley, Craig W; Bender, Aaron M
HIV
血脑屏障
信号转导
神经科学
微生物学
发表日期：2026
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Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma

靶向ST3GAL1以下调糖免疫检查点Siglec-7的配体并逆转肝细胞癌的免疫逃逸

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-026-04388-x
Fan, Tan-Chi; Hung, Tsai-Hsien; Yeh, Chau-Ting; Lin, Po-Ting; Chang, Nai-Chuan; Lo, Tzu-Chi; Wu, Tsai-Jung; Yu, John; Yu, Alice L
细胞生物学
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2026
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Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis

联合靶向聚（ADP-核糖）聚合酶和受体酪氨酸激酶可通过干扰核糖体生物合成抑制卵巢透明细胞癌的进展。

期刊:Journal of Molecular Medicine-Jmm
影响因子:4.2
doi:10.1007/s00109-026-02638-0
Lin, Chiao-Yun; Chao, An-Shine; Chao, Angel; Wu, Ren-Chin; Yu, Alice L; Fu, Chiung-Hui; Teng, Yu-Chuan; Huang, Ruby Yun-Ju; Lai, Chyong-Huey
信号转导
细胞生物学
肿瘤
肿瘤免疫
发表日期：2026
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Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy

VU6025733 (AG06827) 的发现：一种高选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM)，具有强大的体内疗效

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00963
Gregro, Alison R; Park, Charlotte; Long, Madeline F; Baker, Logan A; Bollinger, Katrina A; Ringuette, Anna E; Peng, Li; Luscombe, Vincent B; Billard, Natasha B; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Dickerson, Jonathan W; Rook, Jerri M; O'Neill, Jordan; Chang, Sichen; Boonen, Harrie C M; Jensen, Thomas; Thomsen, Morten S; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J
信号转导
发表日期：2026
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Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

发现 7-(吡啶-3-基)噻吩并[3,2-b]吡啶-5-甲酰胺类化合物作为代谢型谷氨酸受体5亚型的负变构调节剂

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00896
Henderson, Scott H; Ringuette, Anna E; Whomble, David L; Capstick, Rory A; Richardson, Alexa E; Maurer, Mallory A; Billard, Natasha B; Lei, Xia; Wilkinson, Joshua C; Kethanapalli, Sri H; Cho, Hyekyung P; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Rook, Jerri M; Chang, Sichen; Blobaum, Anna L; Boutaud, Olivier; Felts, Andrew S; Conn, P Jeffrey; Lindsley, Craig W; Temple, Kayla J
信号转导
代谢
发表日期：2026
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G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments

G-四链体由核苷酸单体在水性环境中自组装而成，形成稳定的预聚物支架。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-38899-5
Eiby, Simon H J; Catley, Thomas E; Gamill, Max C; Pyne, Alice L B; Hassenkam, Tue
发表日期：2026
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Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers

黑色素瘤的免疫图谱：肿瘤微环境、耐药机制和预测性生物标志物

期刊:World Journal of Clinical Oncology
影响因子:3.2
doi:10.5306/wjco.v17.i1.114913
Oliveira, Marina M G L; Lemos, Carol S; Brazão, Mariangela L S; Rodrigues, Alice L A; do Nascimento, Evelin da C; Cardoso, Emylli M P; Arantes, Maria F F; de Melo, Fabrício F
黑色素瘤
肿瘤
肿瘤免疫
肿瘤微环境
免疫/内分泌
发表日期：2026
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ACP4 Variants in Hypoplastic Amelogenesis Imperfecta

釉质发育不全症中的 ACP4 变异

期刊:Calcified Tissue International
影响因子:3.2
doi:10.1007/s00223-026-01512-y
Liu, Lu; Au, Cheuk Wang; Hany, Ummey; Rigby, Alice L; Chauhan, Anesha; Brown, Catriona; Sims, Jessie; Murillo, Gina; Acosta de Carmargo, Marìa Gabriela; Inglehearn, Chris F; Watson, Christopher M; Mighell, Alan J; Smith, Claire E L
发育与干细胞
发表日期：2026
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