日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

生物分子凝聚体中RNA的选择性隔离决定细胞命运的转变

Pessina, Patrizia; Nevo, Mika; Shi, Junchao; Kodali, Srikanth; Casas, Eduard; Cui, Yingzhi; Richards, Alicia L; Park, Emily J; Chen, Xi; Levin-Ferreyra, Florencia; Rivera Tostado, Alejandra; Stevenson, Erica; Krogan, Nevan J; Swaney, Danielle L; Ying, Qilong; Chen, Qi; Brumbaugh, Justin; Di Stefano, Bruno

Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection

病毒感染后,浆细胞样树突状细胞产生的I型干扰素减少是由代谢缺陷引起的。

Trever T Greene ,Yeara Jo ,Carolina Chiale ,Monica Macal ,Ziyan Fang ,Fawziyah S Khatri ,Alicia L Codrington ,Katelynn R Kazane ,Elizabeth Akbulut ,Shobha Swaminathan ,Yu Fujita ,Patricia Fitzgerald-Bocarsly ,Thekla Cordes ,Christian Metallo ,David A Scott ,Elina I Zúñiga

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation

G蛋白偶联受体ADGRG1通过激活MYC驱动阿尔茨海默病中小胶质细胞的保护性状态。

Beika Zhu,Andi Wangzhou,Diankun Yu,Tao Li,Rachael Schmidt,Stacy L De Florencio,Lauren Chao,Alicia L Thurber,Minqi Zhou,Zeina Msheik,Yonatan Perez,Lea T Grinberg,Salvatore Spina,Richard M Ransohoff,Arnold R Kriegstein,William W Seeley,Tomasz Nowakowski,Xianhua Piao

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation

G蛋白偶联受体ADGRG1通过激活MYC驱动阿尔茨海默病中小胶质细胞的保护性状态。

Beika Zhu ,Andi Wangzhou ,Diankun Yu ,Tao Li ,Rachael Schmidt ,Stacy L De Florencio ,Lauren Chao ,Alicia L Thurber ,Minqi Zhou ,Zeina Msheik ,Yonatan Perez ,Lea T Grinberg ,Salvatore Spina ,Richard M Ransohoff ,Arnold R Kriegstein ,William W Seeley ,Tomasz Nowakowski ,Xianhua Piao

Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

将IL-2与IL-10偶联可减轻毒性并增强抗肿瘤免疫力

Julie J Ahn,Steven Dudics,David P Langan,Jeffrey D Smith,Alice H Hsu,Jacob C McCright,Sawyer R Smith,Alicia L Castleberry,Benjamin I George,Javier A Goitía Vázquez,Phillip N Kuri,Sri Sai Vivek Alla,Jennifer Garcia,Young Min Haider,Fatima W Hamdan,Jhonnatan Esquivel Juárez,Robert Reddy,Aranganathan Shanmuganathan,Yuanyuan Wang,Arielle Welch,David Boclair,Pavel A Khrimian,Christopher H Yaen,John B Mumm

Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

将IL-2与IL-10偶联可减轻毒性并增强抗肿瘤免疫力

Julie J Ahn ,Steven Dudics ,David P Langan ,Jeffrey D Smith ,Alice H Hsu ,Jacob C McCright ,Sawyer R Smith ,Alicia L Castleberry ,Benjamin I George ,Javier A Goitía Vázquez ,Phillip N Kuri ,Sri Sai Vivek Alla ,Jennifer Garcia ,Young Min Haider ,Fatima W Hamdan ,Jhonnatan Esquivel Juárez ,Robert Reddy ,Aranganathan Shanmuganathan ,Yuanyuan Wang ,Arielle Welch ,David Boclair ,Pavel A Khrimian ,Christopher H Yaen ,John B Mumm

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

A roadmap to understanding and anticipating microbial gene transfer in soil communities

理解和预测土壤群落中微生物基因转移的路线图

Gillett, David L; Selinidis, Malyn; Seamons, Travis; George, Dalton; Igwe, Alexandria N; Del Valle, Ilenne; Egbert, Robert G; Hofmockel, Kirsten S; Johnson, Alicia L; Matthews, Kirstin R W; Masiello, Caroline A; Stadler, Lauren B; Chappell, James; Silberg, Jonathan J

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Immunization induces inflammation in the mouse heart during spaceflight

免疫接种会在小鼠太空飞行期间诱发心脏炎症。

Veliz, Alicia L; Hughes, Lorelei; Carrillo, Delia; Pecaut, Michael J; Kearns-Jonker, Mary