日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular LEGION: incalculably large coverage of chemical space around the NLRP3 target

分子军团:对 NLRP3 靶标周围化学空间的覆盖范围极其广泛

Zagribelnyy, Bogdan; Aladinskiy, Vladimir; Bondarev, Nikita; Ilin, Ivan; Malkov, Maxim; Vasileva, Anna; Ding, Xiaoyu; Lin, Arkadii; Shayakhmetov, Rim; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex

Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors

量子计算增强算法揭示潜在的KRAS抑制剂

Ghazi Vakili, Mohammad; Gorgulla, Christoph; Snider, Jamie; Nigam, AkshatKumar; Bezrukov, Dmitry; Varoli, Daniel; Aliper, Alex; Polykovsky, Daniil; Padmanabha Das, Krishna M; Cox Iii, Huel; Lyakisheva, Anna; Hosseini Mansob, Ardalan; Yao, Zhong; Bitar, Lela; Tahoulas, Danielle; Čerina, Dora; Radchenko, Eugene; Ding, Xiao; Liu, Jinxin; Meng, Fanye; Ren, Feng; Cao, Yudong; Stagljar, Igor; Aspuru-Guzik, Alán; Zhavoronkov, Alex

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

小分子 TNIK 抑制剂针对临床前和临床模型中的纤维化

Feng Ren, Alex Aliper, Jian Chen, Heng Zhao, Sujata Rao, Christoph Kuppe, Ivan V Ozerov, Man Zhang, Klaus Witte, Chris Kruse, Vladimir Aladinskiy, Yan Ivanenkov, Daniil Polykovskiy, Yanyun Fu, Eugene Babin, Junwen Qiao, Xing Liang, Zhenzhen Mou, Hui Wang, Frank W Pun, Pedro Torres-Ayuso, Alexander V

Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation.

利用人工智能生成技术发现双功能PKMYT1靶向PROTAC。

Wang Yazhou, Wang Xiaomin, Liu Tingting, Wang Chao, Meng Qingshuo, Meng Fanye, Yu Jiaojiao, Liu Jinxin, Fan Yaya, Gennert David, Pun Frank W, Aliper Alex, Ren Feng, Zhang Man, Cai Xin, Ding Xiao, Zhavoronkov Alex

A novel, covalent broad-spectrum inhibitor targeting human coronavirus M(pro).

一种新型的、针对人类冠状病毒 M(pro) 的共价广谱抑制剂

Sun Jing, Sun Deheng, Yang Qi, Wang Dong, Peng Jingjing, Guo Hu, Ding Xiaoyu, Chen Zhao, Yuan Bin, Ivanenkov Yan A, Yuan Jinwei, Zagribelnyy Bogdan A, He Yiyun, Su Jingyi, Wang Ling, Tang Jielin, Li Zhun, Li Rong, Li Taotao, Hu Xiaoyu, Liang Xing, Zhu Airu, Wei Peilan, Fan Yaya, Liu Sang, Zheng Jie, Guan Xin, Aliper Alex, Yang Minglei, Bezrukov Dmitry S, Xie Zhanhong, Terentiev Victor A, Peng Guilin, Polykovskiy Daniil A, Malyshev Alexander S, Malkov Maxim N, Zhu Qingsong, Aspuru-Guzik Alán, Ding Xiao, Cai Xin, Zhang Man, Zhao Jingxian, Zhong Nanshan, Ren Feng, Chen Xinwen, Zhavoronkov Alex, Zhao Jincun

A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development

临床前药物研发中小鼠寿命研究的标准化方案

Zhavoronkov, Alex; Wang, Qian; Liu, Yujie; Hou, Wenbin; Shen, Yuelei; Wilczok, Dominika; Fortney, Kristen; Aliper, Alex; Zhang, Man; Ren, Feng; Miller, Richard A

Variability in radiotherapy outcomes across cancer types: a comparative study of glioblastoma multiforme and low-grade gliomas

不同癌症类型放射治疗效果的差异:胶质母细胞瘤和低级别胶质瘤的比较研究

Veviorskiy, Alexander; Mkrtchyan, Garik V; Osipov, Andreyan N; Izumchenko, Evgeny; Ozerov, Ivan V; Aliper, Alex; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

nach0: multimodal natural and chemical languages foundation model

nach0:多模态自然语言和化学语言基础模型

Livne, Micha; Miftahutdinov, Zulfat; Tutubalina, Elena; Kuznetsov, Maksim; Polykovskiy, Daniil; Brundyn, Annika; Jhunjhunwala, Aastha; Costa, Anthony; Aliper, Alex; Aspuru-Guzik, Alán; Zhavoronkov, Alex

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation

Precious2GPT:结合多组学预训练Transformer和条件扩散算法,用于人工生成多组学、多物种、多组织样本。

Sidorenko, Denis; Pushkov, Stefan; Sakip, Akhmed; Leung, Geoffrey Ho Duen; Lok, Sarah Wing Yan; Urban, Anatoly; Zagirova, Diana; Veviorskiy, Alexander; Tihonova, Nina; Kalashnikov, Aleksandr; Kozlova, Ekaterina; Naumov, Vladimir; Pun, Frank W; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex

AttenhERG: a reliable and interpretable graph neural network framework for predicting hERG channel blockers

AttenhERG:一个可靠且可解释的图神经网络框架,用于预测hERG通道阻滞剂

Yang, Tianbiao; Ding, Xiaoyu; McMichael, Elizabeth; Pun, Frank W; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex; Ding, Xiao