日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons

GIRK2 上调可抵消乙醇诱导的人类神经元兴奋性和呼吸作用的变化

Iya Prytkova ,Yiyuan Liu ,Michael Fernando ,Isabel Gameiro-Ros ,Dina Popova ,Chella Kamarajan ,Xiaoling Xuei ,David B Chorlian ,Howard J Edenberg ,Jay A Tischfield ,Bernice Porjesz ,Zhiping P Pang ,Ronald P Hart ,Alison Goate ,Paul A Slesinger

Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice

人类小胶质细胞中的常染色体显性阿尔茨海默病突变不足以引发野生小鼠的淀粉样蛋白病理,但可能影响 5XFAD 小鼠的病理

Carmen Romero-Molina, Sarah M Neuner, Marcelina Ryszawiec, Alice Pébay, Dominantly Inherited Alzheimer Network, Edoardo Marcora, Alison Goate

Sex specific molecular networks and key drivers of Alzheimer's disease

性别特异性分子网络和阿尔茨海默病的关键驱动因素

Lei Guo #, Jiqing Cao #, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia-Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang7

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

酒精逆转了 KCNJ6(GIRK2)非编码变体对人类谷氨酸能神经元兴奋性的影响

Dina Popova, Isabel Gameiro-Ros, Mark M Youssef, Petronio Zalamea, Ayeshia D Morris, Iya Prytkova, Azadeh Jadali, Kelvin Y Kwan, Chella Kamarajan, Jessica E Salvatore, Xiaoling Xuei, David B Chorlian, Bernice Porjesz, Samuel Kuperman, Danielle M Dick, Alison Goate, Howard J Edenberg, Jay A Tischfiel

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

利用CRISPRi技术筛选人iPSC衍生的星形胶质细胞,可以阐明不同炎症反应状态的调节因子。

Kun Leng ,Indigo V L Rose ,Hyosung Kim ,Wenlong Xia ,Wilber Romero-Fernandez ,Brendan Rooney ,Mark Koontz ,Emmy Li ,Yan Ao ,Shinong Wang ,Mitchell Krawczyk ,Julia Tcw ,Alison Goate ,Ye Zhang ,Erik M Ullian ,Michael V Sofroniew ,Stephen P J Fancy ,Matthew S Schrag ,Ethan S Lippmann ,Martin Kampmann

Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models

干细胞衍生神经模型的细胞类型特异性体外基因表达谱分析

James A Gregory ,Emily Hoelzli ,Rawan Abdelaal ,Catherine Braine ,Miguel Cuevas ,Madeline Halpern ,Natalie Barretto ,Nadine Schrode ,Güney Akbalik ,Kristy Kang ,Esther Cheng ,Kathryn Bowles ,Steven Lotz ,Susan Goderie ,Celeste M Karch ,Sally Temple ,Alison Goate ,Kristen J Brennand ,Hemali Phatnani

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

配对免疫球蛋白样 2 型受体 Alpha G78R 变体可改变配体结合并对阿尔茨海默病提供保护

Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele

携带 CHRNA5 N398 等位基因的 iPSC 衍生人类神经元对尼古丁的反应增强

Eileen N Oni, Apoorva Halikere, Guohui Li, Alana J Toro-Ramos, Mavis R Swerdel, Jessica L Verpeut, Jennifer C Moore, Nicholas T Bello, Laura J Bierut, Alison Goate, Jay A Tischfield, Zhiping P Pang, Ronald P Hart

A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele

剪接产生的补偿效应使 CYP2A6*14 等位基因功能正常

A Joseph Bloom, Oscar Harari, Maribel Martinez, Xiaochun Zhang, Sandra A McDonald, Sharon E Murphy, Alison Goate

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis

外显子组测序证实 DNAJC5 突变是导致成人神经元蜡样脂褐素沉积症的原因

Bruno A Benitez, David Alvarado, Yefei Cai, Kevin Mayo, Sumitra Chakraverty, Joanne Norton, John C Morris, Mark S Sands, Alison Goate, Carlos Cruchaga