日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson's Disease

整合应激反应特征驱动GBA1和LRRK2相关帕金森病中的单核细胞功能障碍

Mattei, Daniele; Brophy, Erica; Rosen, Mikaela; Majos, Oriol Narcis; Domingo, Aloysius; Meijia, Elena; De Sanctis, Claudia; Jang, Beomjin; Khashan, Tarek; Yang, Mengxi; Raymond, Deborah; Young, Casey; Humphrey, Jack; Navarro, Elisa; Allan, Amanda; Leaver, Katherine; Katsnelson, Viktoriya; Chung, Alexander; Muller, Benjamin; Swan, Matthew; Shanker, Vicki L; Pullman, Mariel; Wise, Adina Wise Adina; Ortega, Roberto; Astudillo, Kelly; Frucht, Steven; Bressman, Susan; Riboldi, Giulietta; Ozelius, Laurie J; Saunders-Pullman, Rachel; Raj, Towfique

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson's Disease

整合应激反应特征驱动GBA1和LRRK2相关帕金森病中的单核细胞功能障碍

Mattei, Daniele; Brophy, Erica; Rosen, Mikaela; Majos, Oriol Narcis; Domingo, Aloysius; Meijia, Elena; Jang, Beomjin; Khashan, Tarek; Yang, Mengxi; Raymond, Deborah; Young, Casey; Humphrey, Jack; Navarro, Elisa; Allan, Amanda; Leaver, Katherine; Katsnelson, Viktoriya; Chung, Alexander; Muller, Benjamin; Swan, Matthew; Shanker, Vicki L; Pullman, Mariel; Wise, Adina; Ortega, Roberto; Astudillo, Kelly; Frucht, Steven; Bressman, Susan; Riboldi, Giulietta; Ozelius, Laurie J; Saunders-Pullman, Rachel; Raj, Towfique

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.

髓系细胞受到促炎刺激后,胞嘧啶到尿嘧啶的 RNA 编辑会上调

Seo Hyomin, Cuddleston Winston H, Fu Ting, Navarro Elisa, Parks Madison, Allan Amanda, Efthymiou Anastasia G, Breen Michael S, Xiao Xinshu, Raj Towfique, Humphrey Jack

LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment.

LRRK2 G2019S 变异与帕金森病人类髓系细胞在促炎环境下的转录变化有关

Navarro Elisa, Efthymiou Anastasia G, Parks Madison, Riboldi Giulietta M, Vialle Ricardo A, Udine Evan, Muller Benjamin Z, Humphrey Jack, Allan Amanda, Argyrou Charlie Charalambos, Lopes Katia de Paiva, Münch Alexandra, Raymond Deborah, Sachdev Rivka, Shanker Vicki L, Miravite Joan, Katsnelson Viktoryia, Leaver Katherine, Frucht Steve, Bressman Susan B, Marcora Edoardo, Saunders-Pullman Rachel, Goate Alison, Raj Towfique

Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing.

新型小胶质细胞亚型的长读长 RNA-seq 图谱阐明了与疾病相关的剪接基因调控

Humphrey Jack, Brophy Erica, Kosoy Roman, Zeng Biao, Coccia Elena, Mattei Daniele, Ravi Ashvin, Efthymiou Anastasia G, Navarro Elisa, Muller Benjamin Z, Snijders Gijsje Jlj, Allan Amanda, Münch Alexandra, Kitata Reta Birhanu, Kleopoulos Steven P, Argyriou Stathis, Shao Zhiping, Francoeur Nancy, Tsai Chia-Feng, Gritsenko Marina A, Monroe Matthew E, Paurus Vanessa L, Weitz Karl K, Shi Tujin, Sebra Robert, Liu Tao, de Witte Lot D, Goate Alison M, Bennett David A, Haroutunian Vahram, Hoffman Gabriel E, Fullard John F, Roussos Panos, Raj Towfique

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

对人类小胶质细胞转录组在不同脑区、衰老和疾病病理学中的遗传分析

Lopes, Katia de Paiva; Snijders, Gijsje J L; Humphrey, Jack; Allan, Amanda; Sneeboer, Marjolein A M; Navarro, Elisa; Schilder, Brian M; Vialle, Ricardo A; Parks, Madison; Missall, Roy; van Zuiden, Welmoed; Gigase, Frederieke A J; Kübler, Raphael; van Berlekom, Amber Berdenis; Hicks, Emily M; Bӧttcher, Chotima; Priller, Josef; Kahn, René S; de Witte, Lot D; Raj, Towfique