日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

在唐氏综合征和阿尔茨海默病小鼠模型中,母体补充胆碱可在三种海马兴奋性神经元群中产生独特的表达谱嵌合体

Alldred, Melissa J; Ibrahim, Kyrillos W; Pidikiti, Harshitha; Lee, Sang Han; Heguy, Adriana; Chiosis, Gabriela; Mufson, Elliott J; Stutzmann, Grace E; Ginsberg, Stephen D

Benefits of Maternal Choline Supplementation on Aged Basal Forebrain Cholinergic Neurons (BFCNs) in a Mouse Model of Down Syndrome and Alzheimer's Disease

母体补充胆碱对唐氏综合征和阿尔茨海默病小鼠模型中衰老基底前脑胆碱能神经元(BFCNs)的益处

Alldred, Melissa J; Pidikiti, Harshitha; Ibrahim, Kyrillos W; Lee, Sang Han; Heguy, Adriana; Chiosis, Gabriela; Mufson, Elliott J; Stutzmann, Grace E; Ginsberg, Stephen D

Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

对海马神经元群体的分析揭示了独特的基因表达镶嵌,反映了唐氏综合征和阿尔茨海默病 Ts65Dn 小鼠模型中基于连接的退化

Alldred Melissa J, Ibrahim Kyrillos W, Pidikiti Harshitha, Lee Sang Han, Heguy Adriana, Chiosis Gabriela, Mufson Elliott J, Stutzmann Grace E, Ginsberg Stephen D

Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain

衰老而非基因型才是导致靶向替换APOE2、APOE3和APOE4小鼠脑内基因表达差异的主要因素。

Labuza, Amanda; Pidikiti, Harshitha; Alldred, Melissa J; Ibrahim, Kyrillos W; Peng, Katherine Y; Pasato, Jonathan; Heguy, Adriana; Mathews, Paul M; Ginsberg, Stephen D

Profiling lamina specific pyramidal neurons using postmortem human formalin fixed paraffin embedded frontal cortex tissue in combination with digital spatial profiling.

利用死后人类福尔马林固定石蜡包埋额叶皮层组织结合数字空间分析技术,对特定层锥体神经元进行分析

Stanisavljevic Aleksandra, Ibrahim Kyrillos W, Stavrides Philip H, Bare Christopher, Alldred Melissa J, Heguy Adriana, Nixon Ralph A, Ginsberg Stephen D

Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments.

早期生活前额叶皮层抑制和早期生活压力会导致长期的行为、转录和生理障碍

Menezes Edênia C, Geiger Heather, Abreu Fabiula F, Rachmany Lital, Wilson Donald A, Alldred Melissa J, Castellanos Francisco X, Fu Rui, Sargin Derya, Corvelo André, Teixeira Cátia M

Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome.

对微分离的前额皮质兴奋性第 III 层和第 V 层锥体神经元的分析揭示了唐氏综合征患者的神经退行性表型

Alldred Melissa J, Pidikiti Harshitha, Ibrahim Kyrillos W, Lee Sang Han, Heguy Adriana, Hoffman Gabriel E, Roussos Panos, Wisniewski Thomas, Wegiel Jerzy, Stutzmann Grace E, Mufson Elliott J, Ginsberg Stephen D

Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

唐氏综合征患者的前额皮质第三层和第五层锥体神经元在老年个体中表现出层特异性退化。

Alldred, Melissa J; Ibrahim, Kyrillos W; Pidikiti, Harshitha; Chiosis, Gabriela; Mufson, Elliott J; Stutzmann, Grace E; Ginsberg, Stephen D

Hippocampal CA1 Pyramidal Neurons Display Sublayer and Circuitry Dependent Degenerative Expression Profiles in Aged Female Down Syndrome Mice

老年唐氏综合征雌性小鼠海马CA1锥体神经元表现出亚层和回路依赖性的退行性表达谱

Alldred, Melissa J; Pidikiti, Harshitha; Ibrahim, Kryillos W; Lee, Sang Han; Heguy, Adriana; Hoffman, Gabriel E; Mufson, Elliott J; Stutzmann, Grace E; Ginsberg, Stephen D

Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging.

在衰老过程中,载脂蛋白 E2 的表达会改变小鼠模型中脑外泌体水平升高时的内体通路

Peng Katherine Y, Liemisa Braison, Pasato Jonathan, D'Acunzo Pasquale, Pawlik Monika, Heguy Adriana, Penikalapati Sai C, Labuza Amanda, Pidikiti Harshitha, Alldred Melissa J, Ginsberg Stephen D, Levy Efrat, Mathews Paul M