日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designed Water Capture in Terpene Synthase Catalysis

萜烯合酶催化中的水捕获设计

Srivastava, Prabhakar L; Miller, David J; Allemann, Rudolf K

Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation

模拟引导的工程改造实现了塞利那二烯合酶向羟基化的功能转换

Srivastava, Prabhakar L; Johns, Sam T; Voice, Angus; Morley, Katharine; Escorcia, Andrés M; Miller, David J; Allemann, Rudolf K; van der Kamp, Marc W

Single Point Mutation Abolishes Water Capture in Germacradien-4-ol Synthase

单点突变消除吉马曲烯-4-醇合酶中的水捕获作用

González Requena, Víctor; Srivastava, Prabhakar L; Miller, David J; Allemann, Rudolf K

Active Site Loop Engineering Abolishes Water Capture in Hydroxylating Sesquiterpene Synthases

活性位点环工程消除了倍半萜羟基化合成酶中的水捕获

Srivastava, Prabhakar L; Johns, Sam T; Walters, Rebecca; Miller, David J; Van der Kamp, Marc W; Allemann, Rudolf K

Spatio-Temporal Photoactivation of Cytotoxic Proteins

细胞毒性蛋白的时空光活化

Cruz-Samperio, Raquel; Mart, Robert J; Luk, Louis Y P; Tsai, Yu-Hsuan; Jones, Arwyn T; Allemann, Rudolf K

Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis

重新设计分子调控机制以防止锗烯-11-醇合酶催化中的羟基化

Srivastava, Prabhakar L; Escorcia, Andrés M; Huynh, Florence; Miller, David J; Allemann, Rudolf K; van der Kamp, Marc W

Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins

角鲨烯合酶的双膦酸盐抑制剂可保护细胞免受胆固醇依赖性细胞溶解素的侵害

Pospiech, Mateusz; Owens, Siân E; Miller, David J; Austin-Muttitt, Karl; Mullins, Jonathan G L; Cronin, James G; Allemann, Rudolf K; Sheldon, I Martin

Cryo-kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase

低温动力学揭示了动态效应对人二氢叶酸还原酶化学性质的影响

Adesina, Aduragbemi S; Luk, Louis Y P; Allemann, Rudolf K

Accelerating Biphasic Biocatalysis through New Process Windows

通过新的工艺窗口加速双相生物催化

Huynh, Florence; Tailby, Matthew; Finniear, Aled; Stephens, Kevin; Allemann, Rudolf K; Wirth, Thomas

Electric Field Measurements Reveal the Pivotal Role of Cofactor-Substrate Interaction in Dihydrofolate Reductase Catalysis.

电场测量揭示辅因子-底物相互作用在二氢叶酸还原酶催化中的关键作用

Adesina Aduragbemi S, Świderek Katarzyna, Luk Louis Y P, Moliner Vicent, Allemann Rudolf K